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see mutationmutation,
in biology, a sudden, random change in a gene, or unit of hereditary material, that can alter an inheritable characteristic. Most mutations are not beneficial, since any change in the delicate balance of an organism having a high level of adaptation to its environment
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a physical or chemical substance that causes permanent hereditary change.

Physical mutagens include ultraviolet radiation and all kinds of ionizing radiation, such as gamma rays, X rays, protons, and neutrons. High and low temperatures are much less capable of causing mutations.

As study intensifies, the list of compounds with mutagenic action grows longer. Among the chemical mutagens are many alkylating compounds, for example, mustard gas, dimethyl sulfate, and nitrosomethylurea; analogs of nitrogenous bases of the nucleic acids, for example, 5-bromouracil and 2-aminopurine; acridine dyes; nitrous acid; some alkaloids; formaldehyde; hydrogen peroxide and some organic peroxides; and some bio-polymers, for example, heterologous DNA and, apparently, heterologous RNA.

The most powerful chemical mutagens, which increase the frequency of mutations hundreds of times, are called super-mutagens. Some viruses might also be considered chemical mutagens, since the mutagenic factor in viruses seems to be located in their DNA or RNA.

Mutagens are apparently universal, that is, they can cause mutations in all forms of life—from viruses and bacteria to the higher plants, animals, and man. Various species differ in their mutability, that is, their sensitivity to mutagens. None of the known mutagens appear to have a lower limit of mutagenic action. However, the frequency of induced mutations decreases with the decreasing dose of mutagen to a point that matches the frequency of spontaneous mutations regularly occurring in the absence of any mutagen.

Physical and chemical mutagens are widely used in breeding agriculturally useful plants and useful microorganisms. Once the mutation is induced, the mutant is artificially removed from the population and bred as a separate species. These mutations are used in artificial selection.


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An agent that raises the frequency of mutation above the spontaneous or background rate.


a substance or agent that can induce genetic mutation
References in periodicals archive ?
An aromatic component (Diacetyl) is one of the identified mutagens, as is the closely related methyl glyoxal, which is highly mutagenic in bacteria,
This tool enabled them to estimated participants' intake of meat mutagens based on their meat consumption.
Natural compounds in the human diet and their ability to bind mutagens prevents DNA-mutagen intercalation.
In comparative response studies of physical and chemical mutagens, EMS was observed to be more effective and efficient than physical mutagens like (gamma) -rays (Gaikwad and Kothekar, 2004; Giri and Aprao, 2011).
UV and MNNG have been frequently reported as effective mutagens for strain improvement (Zia et al., 2010).
fistulosus seeds with chemical mutagens. For induced mutation with chemical mutagens, 0.05% (0.05 g/100 mL) and 0.10% (0.1 g/ 100 mL) of ethidium bromide (ACROS) and 0.01% (0.01 g/100 mL) and 0.02% (0.02 g/100 mL) of colchicine (ACROS) were prepared.
Only a few studies have examined the association between meat mutagens and risk of CRC, and the results are inconsistent.
These mutations act as cores for mutagens that cause DNA damage through various mechanisms.
Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.
The exploit of physical mutagens like X-rays gamma rays and neutrons and chemical mutagens for inducing variation is well recognized and has been used in agriculture.
Ionizing radiations and chemical mutagens provide opportunity to the breeder to enhance the mutation frequency [6].