genetic load

(redirected from Mutational load)
Also found in: Dictionary, Medical.
Related to Mutational load: Genetic burden

genetic load

[jə¦ned·ik ′lōd]
(genetics)
The reduction in fitness of a diploid population due to new mutant genes and those already in the gene pool.
References in periodicals archive ?
It is known to be resistant to conventional chemotherapy, and although DM tumors typically have high mutational loads, they generally lack driver mutations that could be treated with targeted agents, the investigators noted.
Targeted Gene Correction Minimally Impacts Whole-Genome Mutational Load in Human-Disease-Specific Induced Pluripotent Stem Cell Clones"; Cell Stem Cell, 2014; 15 (1): 31 DOI: 10.
The evidence for high nucleotide polymorphism in the Pacific oyster is interesting in light of recent experimental evidence for a high mutational load in this species (Launey & Hedgecock 2001, Bucklin 2002).
In contrast, the KRAS mutational load in chronic pancreatitis was 6.
At the a = 0 line (no asexuality), a sharp threshold of mutational load and equilibrium inbreeding depression is observed, as in Lande et al.
Edison Liu: First will be the conceptual advance in understanding the detailed genetic mutations and mutational load of human cancers.
The effects of selection in the gametophyte stage on mutational load.
Some uncertainty as to how such mutation rates may influence extinction probability in polyploid taxa remains, however, as mutational load may be reduced in polyploids (Lande and Schemske 1985).
This results in a lower mutational load in a gametes than in A gametes, an effect that is intensified when either allele is a rare recessive.
Most studies suggest that inbreeding depression is predominantly caused by the expression of the mutational load of deleterious recessive alleles (the "dominance hypothesis," Crow 1948, 1952; Charlesworth and Charlesworth 1987; Johnston and Schoen 1995), but exposure of the segregational load could also contribute to inbreeding depression (the "overdominance hypothesis," Crow 1948, 1952; Mitton 1993).
Third, Lande (1994) considered only the mutational load due to mutations that have gone to fixation, ignoring the pool of segregating mutations.