The report reviews pipeline therapeutics for Dravet Syndrome (Severe Myoclonic Epilepsy
of Infancy) by companies and universities/research institutes based on information derived from company and industry-specific sources
Abbreviations JME --juvenile myoclonic epilepsy
GTCS --generalized tonic-clonic seizures EEG --electroencephalography CAE --childhood absence epilepsy AEDs --antiepileptic drugs MRI --magnetic resonance imaging VPA --valproate TPM --topiramate LTG --lamotrigine LEV --levetiracetam PPR --photoparoxysmal response
Major finding: Adult juvenile myoclonic epilepsy
patients without comorbid psychiatric conditions had quality of life scores that were similar, or higher, than in absence epilepsy controls (P = .
KEY WORDS: Clinical Electroencephalography Juvenile Myoclonic Epilepsy
Used in severe myoclonic epilepsy
in infancy (Dravet's syndrome)
I am personally following at least 25 patients with juvenile myoclonic epilepsy
aged between 7 and 16 years.
Epilepsies with onset in adolescence included juvenile absence epilepsy, juvenile myoclonic epilepsy
, generalized tonic-clonic seizures on awakening, photosensitive epilepsy, mesial temporal lobe epilepsy, progressive myoclonic epilepsy
and other partial or generalized epilepsies.
Today her mum Mandy Flynn opened her heart to the Gazette to raise awareness of severe myoclonic epilepsy
- also known as Dravet Syndrome.
We invited caregivers of 50 patients with temporal lobe epilepsy (TLE) related to mesial temporal sclerosis and caregivers of 50 patients with juvenile myoclonic epilepsy
(JME) to participate.
These include benign rolandic epilepsy, juvenile myoclonic epilepsy
and temporal lobe epilepsy.
Type II syndrome is known as dyssynergia cerebellaris myoclonica; it is an autosomal-recessive, progressive, myoclonic epilepsy
with ataxia secondary to mitochondrial encephalopathy.
A form of progressive myoclonic epilepsy
, it can produce a variety of complications including intellectual disability, various seizure disorders, mental health difficulties, and dementia.