Myopathy

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myopathy

[mī′äp·ə·thē]
(medicine)
Any disease of the muscles. Also known as myopathia.

Myopathy

 

progressive muscular dystrophy; a hereditary disease.

Myopathies can be transmitted as autosomal recessive or dominant, or sex chromosome-linked traits. Myopathies result from metabolic disturbances in muscle cells and a change in the biosynthesis of nucleic acids; the degradation of muscle proteins is considerably more rapid than their biosynthesis. In myopathies, muscles become flaccid and some of the fibers are replaced by fatty tissue. Electron microscopy reveals structural changes in the membranes of muscle cells. The main symptoms of the disease are increasing muscular weakness, symmetrical muscular atrophy, decrease in tendon reflexes and, in the later stages, bone and joint deformity. Autonomic trophic nerve functions are invariably impaired.

Myopathy is treated with anticholinesterase preparations, anabolic hormones, and vitamins B and E. Preventive measures include early diagnosis and detection of the heterozygous carrier state for the myopathy gene by using electrophysiological and biochemical tests.

REFERENCES

Badalian, L. O., V. A. Tabolin, and Iu. V. Vel’tishchev. Nasledstvennye bolezni u detei. Moscow, 1971.
Hausmanowa-Petrusewicz, I. Myshechnye zabolevaniia. Warsaw, 1971. (Translated from Polish.)

L. O. BADALIAN

References in periodicals archive ?
Recent advances suggest that abnormal excitation-contraction coupling may be a common theme in the congenital myopathies [17].
Etiologies of NB Myopathy NB in other neuromuscular disorders AD: NEB, ACTA1, TPM3, TPM2 Myopathy Idiopathic inflammatory myopathies Acute alcoholic myopathy AR: ACTA1, TPM3, TPM2, TNNT1, Myotonic dystrophy CFL2, KBTBD13, KLHL40, Sarcoglycanopathies KLHL41, LMOD3, MYPN, MYO18B Mitochondrial myopathy GYG1 polyglucosan body myopathy Late-onset Pompe disease Acquired Neuropathy MGUS Spinal muscular atrophy HIV-associated myopathy Amyotrophic lateral sclerosis Charcot-Marie-Tooth disease Other Hypothyroidism Chronic renal failure Keys: genes are written in italic font; AD, autosomal dominant; AR, autosomal recessive; NB, nemaline body; MGUS, monoclonal gammopathy of undetermined significance.
Bouvier et al., "High risk of cancer in autoimmune necrotizing myopathies: usefulness of myositis specific antibody," Brain A Journal Of Neurology, vol.
For this prospective study, 49 adult patients with idiopathic inflammatory myopathies (13 males, 36 females) were recruited in West China Hospital of Sichuan University, China, from August 2014 to December 2014.
In the idiopathic inflammatory myopathies (IIM), do reactive oxygen species (ROS) contribute to muscle weakness?
Le Quintrec, "Drug-induced myopathies," Bailliere's Clinical Rheumatology, vol.
Rheumatologists are from Venus: Differences in approach to classifying the idiopathic inflammatory myopathies. Curr Opin Rheumatol 2010;22:623626.
Most of the endocrine myopathies affect proximal limb muscles in the upper and lower limbs.
INTRODUCTION: Myopathies are neuromuscular disorders in which the primary symptom is muscle weakness due to dysfunction of muscle fibre.
Among specific topics are histological and histochemical stains and reactions, how to read a biopsy, muscular distrophies and allied disorders, congenital myopathies and related disorders, myopathies associated with systemic disorders and aging, myasthenic syndromes, and toxic and drug-induced myopathies.