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Related to Myopathy: Mitochondrial myopathy


Any disease of the muscles. Also known as myopathia.



progressive muscular dystrophy; a hereditary disease.

Myopathies can be transmitted as autosomal recessive or dominant, or sex chromosome-linked traits. Myopathies result from metabolic disturbances in muscle cells and a change in the biosynthesis of nucleic acids; the degradation of muscle proteins is considerably more rapid than their biosynthesis. In myopathies, muscles become flaccid and some of the fibers are replaced by fatty tissue. Electron microscopy reveals structural changes in the membranes of muscle cells. The main symptoms of the disease are increasing muscular weakness, symmetrical muscular atrophy, decrease in tendon reflexes and, in the later stages, bone and joint deformity. Autonomic trophic nerve functions are invariably impaired.

Myopathy is treated with anticholinesterase preparations, anabolic hormones, and vitamins B and E. Preventive measures include early diagnosis and detection of the heterozygous carrier state for the myopathy gene by using electrophysiological and biochemical tests.


Badalian, L. O., V. A. Tabolin, and Iu. V. Vel’tishchev. Nasledstvennye bolezni u detei. Moscow, 1971.
Hausmanowa-Petrusewicz, I. Myshechnye zabolevaniia. Warsaw, 1971. (Translated from Polish.)


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Incidence of myopathy in patients treated with antimalarials.
Ghilardi G, Gonvers JJ, So A: Hypothyroid myopathy as a complication of interferon alpha therapy for chronic hepatitis C virus infection.
The company said that in an experimental study carried out in collaboration with researchers at Karolinska Instutet in Stockholm, Sweden, the project's model substance has shown favourable effects, which may counter disease progression in mitochondrial myopathy.
Diagnosis of IMNM was confirmed by muscle biopsies, in which 25 patients showed anti-SRP antibody positivity and 5 patients had statin-related myopathy.
There was no history of allergy, alopecia, oral or genital ulcers, photosensitivity, any eye symptoms, as well as any history suggestive of myopathy.
Based on the wild origin of the bird, recent history of physical restraint, clinical presentation, and abnormal blood test results, the presumed diagnosis was capture myopathy.
Summary: Bioinformatic comparison of RNA-Seq data from diseased and gene therapy treated muscle reveals gene expression patterns that correlate with therapeutic correction of X-Linked Myotubular Myopathy in dogs.
Alcoholic myopathy is common among people with AUD and may manifest as an acute or chronic condition.
GNE myopathy needs both the mother and father to pass on the mutated gene to their offspring, at odds of one in 30million.
We have established that probably the development of statins induced myopathy was not linked to serum Co Q10 levels because concomitant use of Coenzyme Q10 could not prevent the muscular toxicity caused by both toxic and therapeutic doses of simvastatin.
Given the symmetric muscle involvement and positive antinuclear antibody markers, rhabdomyolysis was deemed to be related to an inflammatory myopathy associated with Sjogren's syndrome.
With all statins, the risk of myopathy is also increased by cyclosporine, gemfibrozil and possibly other fibrates.