glycosylation

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glycosylation

[glī‚käs·ə′lā·shən]

(biochemistry)

A chemical reaction in which glycosyl groups are added to a protein to produce a glycoprotein.

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Flavonoid

References in periodicals archive ?

In addition to N-linked glycosylation, O-linked glycosylation is believed to be involved in Nrf1 transcription activity.

Transcriptional regulation of the 26S proteasome by Nrf1

Glycosylation sites analysis showed that one N-linked glycosylation sites (N20) and eight O-linked glycosylation sites (T22, T24, T25, S33, S38, T41, T46 and S269) were found in the amino acid sequence according to NetNGlyc 1.0 Server and NetOGlyc 4.0 Server, respectively.

A Novel Application Potential of GH6 Cellobiohydrolase CtCel6 from Thermophilic Chaetomium thermophilum for Gene Cloning, Heterologous Expression and Biological Characterization

2-DG Interferes with N-Linked Glycosylation (NLG) and Induces Changes in the Metabolic Profile of Leukemic Cells In Vitro.

2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner

The N-linked glycosylation of [MSP1.sub.42]kDa protein was studied using NetNGlyc1.0 server of Technical University of Denmark (http://www.cbs.dtu.dk/services/NetNGlyc).

Heterologous expression and characterization of Plasmodium falciparum Merozoite surface protein 1 ([MSP1.sub.42]kDa) in Pichia pastoris and its in-vitro parasite growth inhibition assay

EX-CELL Glycosylation Adjust (Gal+) is an off-the-shelf protein quality supplement designed to achieve functionally relevant shifts in N-linked glycosylation quickly and efficiently, according to the company, and is highly concentrated, only requiring a small amount of product.

SAFC launches new protein quality supplement

There are 12 potential N-linked glycosylation sites in the receptor, two in each of domains I and II and four in each of domains III and IV [14].

A premature termination of human epidermal growth factor receptor transcription in escherichia coli

This insertion generates N-linked glycosylation. Interestingly, SAA4 is not completely glycosylated; two forms, glycosylated (G) and nonglycosylated (NG), are observed in plasma (Figure 1).

Influence of polymorphism on glycosylation of serum amyloid A4 protein

The eukaryotic N-linked glycosylation pathway is divided in two sequential stages: (a) synthesis in the rough endoplasmic reticulum (rER) of the dolichol-linked glycan precursor Dol-PP-GlcN[Ac.sub.2][Man.sub.3][Glc.sub.3] and its transfer to a nascent protein and (b) the N-linked glycan processing and maturation in the rER and Golgi (Figure 1).

Comparative analysis of protein glycosylation pathways in humans and the fungal pathogen Candida albicans

The transmembrane domain of protein and N-linked glycosylation sites were analyzed using TMHMM Server v.2.0 (http://www.cbs.dtu.dk/services/TMHMM) and NetNGlyc 1.0 Server (http:// www.cbs.dtu.dk/services/NetNGlyc/), respectively.

Characterization of the cDna encoding membrane-bound trehalase, its expression and enzyme activity in bactrocera dorsalis (Diptera: Tephritidae)

The technology is said to genetically ligate an external amino acid domain to a therapeutic protein or peptide candidate which results in additional N-linked glycosylation.

Aequus BioPharma validates proprietary GlycoPolymer technology for extending half-life of therapeutic protein drugs

Integrins, receptors and extracellular matrix (ECM) ligands display altered pattern of N-linked glycosylation in cells undergoing a malignant transformation (Janik et al.

Increased antitumor efficacy by the combined administration of Swainsonine and cisplatin in vivo

Mobility shift caused by addition of tunicamyc in-a N-linked glycosylation inhibitor-to culture indicated the effect of glycosylation on the protein weight and SDS-PAGE protein band pattern.

Expression and purification of functionally active recombinant human alpha 1-antitrypsin in methylotrophic yeast Pichia pastoris