N-methylaniline (NMA) is also a methemoglobinogenic chemical.
N-methylaniline is well absorbed in the respiratory and gastrointestinal tracts and through the skin.
N-methylaniline is not mutagenic in Escherichia coli and does not induce unscheduled synthesis of deoxyribonucleic acid (DNA) in culture of rat hepatocytes, but it induces structural chromosomal aberrations in Chinese hamster lung cells with and without metabolic activation .
The analyzed substance was N-methylaniline CAS No.: 100-61-8, molecular formula: C7H9N (Figure 1), molecular weight: 107.15, synonims: monomethylaniline, N-methylaminobenzene, N-methyl-benzenamine, NMA.
In the prenatal toxicity study, administration of N-methylaniline through-out the embryonic and fetal periods produced embryotoxic effects at doses, range 4-100 mg/kg b.w./day.
Table 3 presents reproductive findings in the rats given N-methylaniline by gavage from the 5th to the 20th day of gestation.
Considering the data obtained in this study, it is reasonable to assume that N-methylaniline administered orally to pregnant rats is toxic for mothers even at a low dose of 0.8 mg/kg b.w./day.