LLC1 cells were used as targets for NK cells
. Seeding density of 4 x [10.sup.4] LLC1 cells/well was considered optimal and used for all assays.
To determine the influence of NK cell
inhibition on tumor cell metastasis, mice were treated with anti-asialo-GM1 antibody and intravenous injections of B16 cells.
HLH is a syndrome of excessive inflammation and tissue destruction, caused by a lack of normal down regulation of activated macrophages and lymphocytes.2 Primary mediator of tissue damage being excessive cytokine production by macrophages, NK cells
, and CTLs.2
It is unclear why individuals respond differently to IFN, (70) but it is supposed to be due, at least in part, to NK cell
characteristics including cell numbers, receptor expression and function alteration.
Miller has more than 20 years of experience studying the biology of NK cells
, and other immune effector cells and their use in clinical immunotherapy with over 170 peer-reviewed publications.
are an essential part of the innate immune system and they play a critical role in protecting the body from cancer.
We analyzed the distribution of NK cell
subpopulations in peripheral blood and decidua.
suggests that there was no significant difference between general anesthesia and spinal anesthesia on NK cell
function after surgery .
function, cytotoxicity and cytokine production, depends on a balance between activating and inhibitory signals triggered by activating and inhibitory receptors (Figure 1) expressed on NK cells
activation and lysis of target cells are determined by both the loss of inhibitory receptor-mediated signaling and presence of activating receptor-mediated signaling.
Intravenous IgG therapy is shown to down-regulate elevated circulating peripheral blood [CD56.sup.+] NK cells
, suggesting an association between increased [CD56.sup.+] NK cell
numbers and unexplained infertility.