GCLC has developed the technology and expertise for the mass production of human NK cells
by successfully conducting a first-in-human clinical trial using healthy donor-derived allogeneic NK cells
and by developing CAR-NKs to enhance anti-tumor specificity and efficacy.
In conjunction, the collaboration combines both breakthrough technologies to develop next generations of specific and hyperactive off-the-shelf NK cells
for allogeneic immuno-oncology therapies.
engineered with chimeric antigen receptors can be targeted to tumors with high specificity.
4,20] At present there is no agreed method for assessing endometrial NK cell
numbers, and currently adopted methods vary greatly in the mean numbers of endometrial NK cells
present, the percentage of endometrial NK cells
versus that of stromal cells, or versus [CD45.
A more recent study found decreased numbers of NK cell
subsets (CD56bright and CD56dim) and an impaired function of NK cells
in patients suffering from TIDM.
Keywords: NK cell
cytotoxicity, Recurrent failed IVF, Soluble fms-like tyrosine kinase 1 (s-FLT-1), Vascular endothelial growth factor.
2 Primary mediator of tissue damage being excessive cytokine production by macrophages, NK cells
, and CTLs.
By building on our knowledge of the activating receptor NKp46, we have generated a technology to specifically induce tumor killing by NK cells
The effect of EVs is directly related to their molecular composition and several studies have ascribed an immunostimulatory effect of EVs to the presence of a very specific molecular content [20, 23, 25-31]; for instance, CD56-positive and perforin-containing EVs from NK cells
can mediate EV-induced cytotoxicity .
27) In vitro, HBV-plasmid DNA promotes NK cell
activation including cytotoxicity and IFN-[gamma] production in the liver through TLR/IFN-[alpha]-mediated signaling pathways.
In addition, the influence on NK cell
activity was investigated, since NK cells
are an important tool of the organism to destroy malignant cells.
In elderly subjects, decreased NK cell
activity is associated with an increased incidence and severity of viral infections such as shingles, influenza, and cytomegalovirus (CMV).