In ACTG 370, 63 patients with dual NRTI experience only (naive to NNRTIs
and protease inhibitors) were randomized to one of 3 regimens.
Ardea also is developing a next-generation NNRTI
for HIV and a next-generation MEK inhibitor for both cancer and inflammatory diseases.
Drug Interactions -- INTELENCE should not be co-administered with the following ARVs: tipranavir/ritonavir, fosamprenavir/ritonavir, atazanavir/ritonavir, full-dose ritonavir (600 mg bid), protease inhibitors administered without ritonavir, and other NNRTIs
Other requirements included having a genotypic test at the beginning of the third HAART regimen and the use of a new PI or NNRTI
with at least one unused NRTI during the first and second HAART regimens.
Preliminary data suggests TMC125 has the potential to be the first NNRTI
active against these resistant strains," said Brian Woodfall, M.
HIV -- Initiate a Phase 2b study of RDEA806 in HIV patients; and -- Initiate a Phase 1 study in normal healthy volunteers of RDEA427, our 2nd generation NNRTI
for the treatment of HIV.
The mutation at position 103 causes cross-resistance with all other approved NNRTIs
Tenofovir naturally substitutes for other nucleoside analogs, not for protease inhibitors or NNRTIs
The Panel on Clinical Practices for the Treatment of HIV Infection classifies efavirenz as a "strongly recommended" NNRTI
30] The ARROW study confirmed this finding, with 83% of children on two NRTIs and an NNRTI
having a viral load of <400 copies/mL after a median of 3.
Upon virologic failure, the emergence of resistance and cross-resistance to the NNRTI
class was higher in the EDURANT arm compared to the EFV arm.
Newer antiretrovirals, used for more treatment-experienced patients, are still in the registration process, such as the second-generation NNRTI
etravirine (ETV) and the integrase inhibitor raltegravir (RLT).