Inhibitor

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Related to NNRTI: nevirapine, HAART, efavirenz, Non-nucleoside reverse transcriptase inhibitors

inhibitor

[in′hib·əd·ər]
(aerospace engineering)
A substance bonded, taped, or dip-dried onto a solid propellant to restrict the burning surface and to give direction to the burning process.
(chemistry)
A substance which is capable of stopping or retarding a chemical reaction; to be technically useful, it must be effective in low concentration.

Inhibitor

 

a circuit having m + n inputs and a single output, at which a signal can appear only when there are no signals on the m inputs (inhibiting). The other n inputs (principal) form one of the two logic connections, “AND” or “OR.” Inhibitors are used extensively in computers. They are very often understood to be a circuit having a single principal input and a single inhibiting input. A signal appears at the output of such a circuit when a signal is present on the principal input but there is none on the inhibiting input. Such an inhibitor is called an anticoincidence gate; its conventional representation is given in Figure 1.

Figure 1. Block diagram of an anticoincidence gate (inhibitor) with m — 1 and n 1:(A) principal input, (Q) inhibiting input, (Ga) anticoincidence gate

inhibitor

A substance added to paint to retard drying, skinning, mildew growth, etc. Also see corrosion inhibitor, inhibiting pigment, drying inhibitor.
References in periodicals archive ?
In ACTG 370, 63 patients with dual NRTI experience only (naive to NNRTIs and protease inhibitors) were randomized to one of 3 regimens.
Ardea also is developing a next-generation NNRTI for HIV and a next-generation MEK inhibitor for both cancer and inflammatory diseases.
Drug Interactions -- INTELENCE should not be co-administered with the following ARVs: tipranavir/ritonavir, fosamprenavir/ritonavir, atazanavir/ritonavir, full-dose ritonavir (600 mg bid), protease inhibitors administered without ritonavir, and other NNRTIs.
Other requirements included having a genotypic test at the beginning of the third HAART regimen and the use of a new PI or NNRTI with at least one unused NRTI during the first and second HAART regimens.
Preliminary data suggests TMC125 has the potential to be the first NNRTI active against these resistant strains," said Brian Woodfall, M.
HIV -- Initiate a Phase 2b study of RDEA806 in HIV patients; and -- Initiate a Phase 1 study in normal healthy volunteers of RDEA427, our 2nd generation NNRTI for the treatment of HIV.
The mutation at position 103 causes cross-resistance with all other approved NNRTIs.
Tenofovir naturally substitutes for other nucleoside analogs, not for protease inhibitors or NNRTIs.
The Panel on Clinical Practices for the Treatment of HIV Infection classifies efavirenz as a "strongly recommended" NNRTI.
30] The ARROW study confirmed this finding, with 83% of children on two NRTIs and an NNRTI having a viral load of <400 copies/mL after a median of 3.
Upon virologic failure, the emergence of resistance and cross-resistance to the NNRTI class was higher in the EDURANT arm compared to the EFV arm.
Newer antiretrovirals, used for more treatment-experienced patients, are still in the registration process, such as the second-generation NNRTI etravirine (ETV) and the integrase inhibitor raltegravir (RLT).