nitric oxide synthase

(redirected from NO synthase)
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nitric oxide synthase

[‚nī·trik ¦äk‚sīd ¦sin‚thās]
(biochemistry)
An enzyme that catalyzes the stepwise conversion of the amino acid L-arginine to nitric oxide and L-citrulline. There are three types: the brain (or neuronal) and epithelial nitric oxide synthases, which are always present in cells, and inducible nitric oxide synthase, which is produced as needed.
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To assess nitrosative stress, adjacent brain sections were stained for nitrotyrosine, inducible NO synthase (iNOS), neuronal NO synthase (nNOS), and endothelial NO synthase (eNOS), respectively.
Nitric oxide is synthesized from L-arginine by the enzyme NO synthase (NOS), of which three isoforms have been identified.
Table 1: Different forms of NO synthase have been classified as follows (14) Name Genes Location Neuronal NOS NOS1 Nervous Tissue (nNOS or NOS1) Skeletal Muscle Type Ii Inducible NOS NOS2 Immune System (iNOS or NOS2) Cardiovascular System Endothelial NOS NOS3 Endothelium (eNOS or NOS3 or cNOS) Bacterial NOS multiple Various Gram(+) Species (bNOS) Name Function Neuronal NOS Cell communication (nNOS or NOS1) Inducible NOS Immune defense against (iNOS or NOS2) pathogens Endothelial NOS Vasodilation (eNOS or NOS3 or cNOS) Bacterial NOS Defense Against Oxidative (bNOS) Stress, Antibiotics, Immune Attack
NO synthase inhibitors such as AG are potential therapeutic agents in the experimental therapy of hemorrhagic shock.
Only recently, the expression of an NO synthase has been also shown in red blood cells (rbcNOS, Kleinbongard et al 2006).
It is synthesized from L-arginine by action of NO synthases (NOSs), an enzyme existing in three isoforms (Moncada et al.
lamblia inhibited epithelial NO production by consuming arginine, the crucial substrate used by epithelial NO synthase to form NO.
Physiological mechanisms regulating the expression of endothelial-type NO synthase.
Muscular structure, enzyme activity, constitutive and inducible nitric oxide (NO) synthases (endothelial NO oxide synthase [eNOS], neuronal NO synthase [nNOS] and inducible NO synthase [iNOS]), nitrites, nitrates, nitrotyrosine, and the presence of macrophages were analyzed.
There are three different forms of NOS: endothelial NO synthases (e NOS), neuronal NO synthase (nNOS) and inducible NO synthase(iNOS).
Alteration of [beta]-cell constitutive NO synthase activity is involved in the abnormal insulin response to arginine in a new rat model of type 2 diabetes.