Glucocorticoid receptor gene (NR3C1
) methylation processes as mediators of early adversity in stress-related disorders causality: A critical review.
Given that amygdala CRH neurons are known targets of glucocorticoid signaling, it is not surprising that altered NR3C1
gene expression has been observed in this region.
(B) Relative mRNA expression of GR (Nr3c1
) was measured by qRT-PCR in adult ADX/OVX control and genistein-exposed mice.
Champagne, "Maternal prenatal depressive symptoms predict infant NR3C1
1F and BDNF IV DNA methylation," Epigenetics, vol.
Devlin, "Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1
) and infant cortisol stress responses," Epigenetics, vol.
The Fkbp5 protein interacted with 2 subtypes of the Nr3c1
The literature has consistently shown that maternal affection has long-lasting effects on the expression of NR3C1
, the gene encoding for the GC receptor, with associated anxious-and/or depressive-like behaviors in animals and humans.
Among the genes, CAPN1, CAST, LEP, ANK1, ADIPOQ, IGF1, NR3C1
, PPARG, and FN1 were included, which were known to be related with marbling, tenderness and juiciness.
Posttraumatic stress disorder (PTSD) produces epigenetic changes in glucocorticoid-related (e.g., NR3C1
) and FKBP5 genes that are transmitted to an affected woman's offspring.
These include multidrug resistance-1 gene (MDR1) encoding P-glycoprotein-170 (P-gp), which transports steroids across the cell membranes [9-12], nuclear receptor subfamily-3 gene (NR3C1
) that encodes cytosolic glucocorticoid receptor (GR) [13, 14], and glucocorticoid-induced transcript 1 gene (GLCCI1) that encodes Glccil protein that associated with glucocorticoid (GC) responsiveness and development of proteinuria in animal models [15,16].
Desta maneira, ha o "silenciamento" do gene NR3C1
(regulador da producao de GRs; Hyman, 2009).
An increased frequency of mutated BclI genotype in the glucocorticoid receptor gene NR3C1
(nuclear receptor subfamily 3, group C, member 1) was described in responsive IBD patients compared with nonresponders but a mutation in the NALP1 gene was significantly more frequent in resistant patients (35).