After randomization, the most commonly selected NRTIs
were tenofovir thsoproxil fumarate/emtricitabine (Truvada) (82%) and tenofovir/ emtricitabine/zidovudine (Retrovir) (12%), according to the late-breaking abstract.
Renal safety of tenofovir disoproxil fumarate in HIV-1 treatment-experienced patients with adverse events related to prior NRTI
use: data from a prospective, observational, multicentre study.
Mutations associated with cross-resistance to NRTIs
in 48% of the participants comprised multiple TAMs (37%), K65R (7.
No major DRMs to NRTIs
or PIs were observed at either time point.
The recommended first-line regimen comprises two NRTIs
in combination with a non-nucleoside reverse transcriptase inhibitor (NNRTI).
resistance develops slowly), in someone who is PI naive it is very likely that virological suppression will be achieved with good adherence, even if the 2 NRTIs
used in second line are partially compromised by NRTI
resistance mutations that have developed during first line.
Hyperlactataemia and lactic acidosis with or without hepatic steatosis can occur with the use of any NRTI
Patterns of prescribing in Europe may have been influenced by the earlier PENTA 5 trial, which compared three NRTI
backbones in children starting HAART: ZDV/3TC, ZDV/ABC and ABC/3TC.
Bristol-Myers Squibb sends a warning letter to healthcare providers regarding pancreatitis with the NRTI
didanosine (Videx, ddI).
htm) described a possible side effect of NRTI
drugs: muscle weakness as a sign of lactic acidosis.
For many years I have been working for the development of medicines in the fight against HIV/AIDS, and I'm convinced that festinavir has the possibility to be a potent and effective NRTI
with a promising resistance profile.
Among those who had received an NRTI
alone, the prevalence was 17%.