In contrast, the MODERN study, comparing DRV/r and MVC (150 mg od) to TDF/FTC/DRV/r, found that the 2DR combination was statistically inferior to the NRTI
containing regimen, and the study was terminated early (30).
In a study conducted in our country with 1306 naive patients, HIV transmitted drug resistance mutations were investigated and resistance to NRTI
, NNRTI and PI was found as 8.1%, 3.3% and 2.3%, respectively .
= nucleoside analogues reverse transcriptase inhibitors.
Some studies have also shown that people treated with AZT have smaller increases in CD4 cell count compared with individuals taking alternative NRTIs
. However, these studies were small and had short duration of follow-up.
resistance develops slowly) in PI-naive patients, it is very likely that virological suppression will be achieved with good adherence, even if the 2 NRTIs
used in second-line are partially compromised by NRTI
resistance mutations (Tables 4 and 5).
Their main goals were to compare rates of viral suppression (defined as having plasma HIV-1 RNA levels of less than 400 copies per ml) in the NRTI
and protease-inhibitor groups and to determine rates of mother-to-child transmission in all three groups.
The dwindling chance of virologic response with each additional prescribed NRTI
may well reflect physicians' perception that people with more resistant virus and fewer active antiretroviral options would benefit from extra nukes.
Two of these studies were conducted in clinically advanced, three-class antiretroviral (NNRT, NRTI
, PI) treatment-experienced adults and one was conducted in treatment-naE[macron]ve adults.
Truvada is a second-line anti-HIV drug in the nucleoside reverse transcriptase inhibitor (NRTI
or "nuke") family and is used in combination with other medications to control HIV infection.
Impact of specific NRTI
and PI exposure on the risk of myocardial infarction: a case-control study nested within FHDH ANRS CO4 16th Conference on Retroviruses and Opportunistic Infections.
As such, regimens of two nucleoside analogue reverse transcriptase inhibitors (NRTI
) plus either a protease inhibitor (PI) or a non-nucleoside reverse transcriptase inhibitor (NNRTI) have been, and still remain the recommended treatment choices.