Inhibitor

(redirected from NRTI)
Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.

inhibitor

[in′hib·əd·ər]
(aerospace engineering)
A substance bonded, taped, or dip-dried onto a solid propellant to restrict the burning surface and to give direction to the burning process.
(chemistry)
A substance which is capable of stopping or retarding a chemical reaction; to be technically useful, it must be effective in low concentration.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Inhibitor

 

a circuit having m + n inputs and a single output, at which a signal can appear only when there are no signals on the m inputs (inhibiting). The other n inputs (principal) form one of the two logic connections, “AND” or “OR.” Inhibitors are used extensively in computers. They are very often understood to be a circuit having a single principal input and a single inhibiting input. A signal appears at the output of such a circuit when a signal is present on the principal input but there is none on the inhibiting input. Such an inhibitor is called an anticoincidence gate; its conventional representation is given in Figure 1.

Figure 1. Block diagram of an anticoincidence gate (inhibitor) with m — 1 and n 1:(A) principal input, (Q) inhibiting input, (Ga) anticoincidence gate

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

inhibitor

A substance added to paint to retard drying, skinning, mildew growth, etc. Also see corrosion inhibitor, inhibiting pigment, drying inhibitor.
McGraw-Hill Dictionary of Architecture and Construction. Copyright © 2003 by McGraw-Hill Companies, Inc.
References in periodicals archive ?
In contrast, the MODERN study, comparing DRV/r and MVC (150 mg od) to TDF/FTC/DRV/r, found that the 2DR combination was statistically inferior to the NRTI containing regimen, and the study was terminated early (30).
In a study conducted in our country with 1306 naive patients, HIV transmitted drug resistance mutations were investigated and resistance to NRTI, NNRTI and PI was found as 8.1%, 3.3% and 2.3%, respectively [17].
NRTI = nucleoside analogues reverse transcriptase inhibitors.
Some studies have also shown that people treated with AZT have smaller increases in CD4 cell count compared with individuals taking alternative NRTIs. However, these studies were small and had short duration of follow-up.
resistance develops slowly) in PI-naive patients, it is very likely that virological suppression will be achieved with good adherence, even if the 2 NRTIs used in second-line are partially compromised by NRTI resistance mutations (Tables 4 and 5).
Their main goals were to compare rates of viral suppression (defined as having plasma HIV-1 RNA levels of less than 400 copies per ml) in the NRTI and protease-inhibitor groups and to determine rates of mother-to-child transmission in all three groups.
The dwindling chance of virologic response with each additional prescribed NRTI may well reflect physicians' perception that people with more resistant virus and fewer active antiretroviral options would benefit from extra nukes.
Two of these studies were conducted in clinically advanced, three-class antiretroviral (NNRT, NRTI, PI) treatment-experienced adults and one was conducted in treatment-naE[macron]ve adults.
Truvada is a second-line anti-HIV drug in the nucleoside reverse transcriptase inhibitor (NRTI or "nuke") family and is used in combination with other medications to control HIV infection.
Impact of specific NRTI and PI exposure on the risk of myocardial infarction: a case-control study nested within FHDH ANRS CO4 16th Conference on Retroviruses and Opportunistic Infections.
As such, regimens of two nucleoside analogue reverse transcriptase inhibitors (NRTI) plus either a protease inhibitor (PI) or a non-nucleoside reverse transcriptase inhibitor (NNRTI) have been, and still remain the recommended treatment choices.