are widely used for mild to moderate pain relief, particularly from arthritis.
TUESDAY, July 17, 2018 (HealthDay News) -- Factors to be considered when choosing the correct nonsteroidal anti-inflammatory drug (NSAID
) for arthritis include effectiveness, concurrent health conditions, and frequency of use, according to a blog post published by the Arthritis Foundation.
For example, two nonrandomized trials comparing NSAIDs
and acetaminophen in patients with quiescent disease found NSAIDs
were associated with frequent, early clinical relapse of IBD.
EFFICACY FOR NECK PAIN: In 2017, Machado, et al, performed a systematic review and meta-analysis of 35 randomized controlled trials which revealed that the magnitude of the difference in outcomes between NSAIDs
and placebo groups is not clinically important for spinal pain.
Of this group, three-quarters (n = 243) received NSAIDs
, while one-quarter (n = 81) did not.
Millions of Britons take NSAIDs
to treat pain and inflammation.
However, most of the reported research has failed to include control groups of patients who were not using NSAIDs
or LDA, so no clear evidence has been gathered on whether gastric and duodenal ulcer symptoms are truly milder for NSAID-induced and LDA-induced ulcers.
The study, published in the British Medical Journal, used data for almost 10 million NSAIDs
users from the UK, Netherlands, Italy and Germany, who started NSAID
treatment between 2000 and 2010.
It found that people who had taken any NSAID
in the previous 14 days had a 19% increased risk of hospital admission for heart failure compared to those who had used NSAIDs
at any point in the past.
"It's been well-known for a number of years that newer types of NSAIDs
-- what are known as COX-2 inhibitors, increase the risk of heart attacks.
In addition to the overall increased cardiovascular risk, taking NSAIDs
puts patients at a higher risk of kidney damage, water retention, heart failure, and bleeding, especially gastrointestinal bleeding.
While some previous studies have linked NSAIDs
to diminished kidney function, the outcome often ignored those who already had hypertension, which itself carries an increased risk for kidney damage.