NSAID

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NSAID:

see nonsteroidal anti-inflammatory drugnonsteroidal anti-inflammatory drug,
a drug that suppresses inflammation in a manner similar to steroids, but without the side effects of steroids; commonly referred to by the acronym NSAID .
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NSAIDs are widely used for mild to moderate pain relief, particularly from arthritis.
Warning: Common Pain Relievers Unsafe for Heart Patients: Fortunately, there are alternatives for those needing daily pain relief
TUESDAY, July 17, 2018 (HealthDay News) -- Factors to be considered when choosing the correct nonsteroidal anti-inflammatory drug (NSAID) for arthritis include effectiveness, concurrent health conditions, and frequency of use, according to a blog post published by the Arthritis Foundation.
Multiple Factors to Consider When Selecting NSAID for Arthritis; Effectiveness, concurrent health conditions, and frequency of use of NSAID should be considered
For example, two nonrandomized trials comparing NSAIDs and acetaminophen in patients with quiescent disease found NSAIDs were associated with frequent, early clinical relapse of IBD.
Mixed outcomes found in analysis of NSAIDs and IBD
NSAID EFFICACY FOR NECK PAIN: In 2017, Machado, et al, performed a systematic review and meta-analysis of 35 randomized controlled trials which revealed that the magnitude of the difference in outcomes between NSAIDs and placebo groups is not clinically important for spinal pain.
Combination of Chiropractic and Exercise as an Alternative to Non-Steroidal Anti-Inflammatory Drugs for the Treatment of Neck Pain: Should a Combination of Chiropractic and Exercise be the First Line of Therapy for Neck Pain? A Commentary on the Available Research
Of this group, three-quarters (n = 243) received NSAIDs, while one-quarter (n = 81) did not.
Postpartum NSAIDs didn't up hypertension risk in preeclampsia
Millions of Britons take NSAIDs to treat pain and inflammation.
PAINKILLERS RAISE HEART ATTACK RISK; Warning for docs over ibuprofen scripts
However, most of the reported research has failed to include control groups of patients who were not using NSAIDs or LDA, so no clear evidence has been gathered on whether gastric and duodenal ulcer symptoms are truly milder for NSAID-induced and LDA-induced ulcers.
Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer?
The study, published in the British Medical Journal, used data for almost 10 million NSAIDs users from the UK, Netherlands, Italy and Germany, who started NSAID treatment between 2000 and 2010.
Painkillers linked to risk of heart failure
It found that people who had taken any NSAID in the previous 14 days had a 19% increased risk of hospital admission for heart failure compared to those who had used NSAIDs at any point in the past.
Ibuprofen link to heart failure
"It's been well-known for a number of years that newer types of NSAIDs -- what are known as COX-2 inhibitors, increase the risk of heart attacks.
Common Painkillers More Dangerous than We Think
In addition to the overall increased cardiovascular risk, taking NSAIDs puts patients at a higher risk of kidney damage, water retention, heart failure, and bleeding, especially gastrointestinal bleeding.
Stronger warnings issued for over-the-counter pain relievers: increased heart attack and stroke risks have been linked with common pain medications
While some previous studies have linked NSAIDs to diminished kidney function, the outcome often ignored those who already had hypertension, which itself carries an increased risk for kidney damage.
NSAIDs increase kidney disease risk

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