DNA

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DNA:

see nucleic acidnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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DNA (deoxyribonucleic acid)

See GENETICS.

DNA

(biochemistry)

DNA

deoxyribonucleic acid; a nucleic acid that is the main constituent of the chromosomes of all organisms (except some viruses). The DNA molecule consists of two polynucleotide chains in the form of a double helix, containing phosphate and the sugar deoxyribose and linked by hydrogen bonds between the complementary bases adenine and thymine or cytosine and guanine. DNA is self-replicating, plays a central role in protein synthesis, and is responsible for the transmission of hereditary characteristics from parents to offspring

DNA

(1) See Windows DNA.

(2) (Digital Network Architecture) Introduced in 1978, it was Digital's umbrella term for its enterprise network architecture based on DECnet.
References in periodicals archive ?
Non-viral vectors include naked DNA, DNA-liposome complexes and DNA-polymer complexes (63,64).
We have considerable experience in using the identical naked DNA for big blood vessel blockages, so we feel very good about the safety, the best way to utilize it, and so forth.
NAKED DNA If viral vectors are risky and nonviral vectors are difficult to develop, why not get rid of the carrier altogether?
The gene can be introduced into a mammalian host by way of an expression vector either as naked DNA or complexed to lipid carriers, particularly cationic lipid carriers.
We thought we would [use] the naked DNA, without the viral vector," says study coauthor Sharon M.
The standard picture of the naked DNA helix is misleading: in cells, the DNA strand is wound round small spherical proteins termed histones to form the complex known as chromatin.
Overall, the company has more than 400 issued or pending patents worldwide, with extensive coverage in the field of naked DNA gene delivery for DNA vaccination and gene-based protein delivery.
Vaccines based on this approach, often called naked DNA vaccines, have taken the first small steps into human trials against AIDS and cancer (SN: 2/17/96, p.
San Diego; 858-646-1127) announced the issuance of United States Patent 6,228,844, which covers naked DNA delivery of Vascular Endothelial Growth Factor (VEGF) to the heart to promote the growth of blood vessels, called angiogenesis.
Whether naked DNA proves useful for vaccines will depend on whether it can be produced in large quantities and whether it has a good safety record, Ulmer adds.
production of the immune-system-stimulating protein the vaccine was coded to produce) of "naked" DNA vaccines by 100-fold or more compared to delivery of naked DNA vaccines via conventional injection alone.