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Related to Necrobiosis: necrobiosis lipoidica diabeticorum


Death of a cell or group of cells under either normal or pathologic conditions.



the change that occurs in a cell prior to cell death. Necrobiosis is linked with metabolic disturbances that may lead to fatty degeneration or to other types of degeneration in the cell. These degenerative changes can be reversible. The most typical symptoms of necrobiosis are changes in the cell nucleus, such as karyopyknosis, karyorrhexis, and karyolysis; disturbances in the viscosity of the cytoplasm; an abnormal staining reaction; and disorganization of the enzyme systems of the cell, which leads to cellular autolysis.

References in periodicals archive ?
Squamous cell carcinoma in an area of necrobiosis lipoidica diabeticorum: a case report.
Necrobiosis lipoidica: treatment with systemic corticosteroids.
Extensive necrobiosis in metastatic Crohn's disease.
Benign inflammatory conditions can also be confused with RDD and include granuloma annulare (palisading granulomas with necrobiosis and mucin accumulation) and inflammatory pseudotumor (vimentin and smooth muscle actin positive, S100 negative).
Variable degree of fibrosis is often present but without necrobiosis of collagen except for those patients with NBX.
Because patients with xanthogranulomas can have plasma cell dyscrasias and lymphoproliferative malignancies, especially in the presence of necrobiosis, a thorough baseline systemic evaluation and long-term follow-up are mandatory.
Epithelioid sarcoma has many histopathologic mimics, including benign and malignant conditions, such as granuloma annulare, necrobiosis lipoidica, chronic granulomatous inflammation (especially rheumatoid nodules), fibrous histocytoma, nodular fasciitis, fibromatosis, giant cell tumor of tendon sheath, melanoma, clear-cell sarcoma of the tendon and aponeurosis (amelanotic melanoma of soft part), schwannoma, metastatic squamous cell carcinoma, metastatic adenocarcinoma (especially renal cell carcinoma), synovial sarcoma, epithelioid hemangioendothelioma, epithelioid leiomyosarcoma, and malignant extrarenal rhabdoid tumors of the soft tissue.