A first to evaluate the relationship between low carbohydrate intake and having children with neural tube
defects, the study was led by Tania Desrosiers, PhD, MPH, and research assistant professor of epidemiology at the UNC Gillings School of Global Public Health.
The petitioners contend that increased consumption of folic acid will reduce the risk of births with neural tube
defects among this group.
While some of the studies were randomized trials, you can no longer conduct a true randomized design and withhold folic acid from women; it's simply not ethical knowing what we know about the preventive benefits of folic acid for neural tube
Folate, homocysteine and neural tube
defects: An over view.
But it has been shown that women who have had a previous child with a neural tube
defect, a high-risk group, need 5 mg/day to have an impact on prevention (Lancet 1991;338:131-7).
defects: prevalence, etiology and prevention.
Since 1998, when grain products first were fortified with folic acid, there has been a decline in neural tube
Furthermore, it appears women with diabetes and poor glucose level management, women of Hispanic descent, non-Hispanic African American women, obese women, those with a prior history of pregnancies affected by neural tube
defects, and women who take antiepileptic drugs are at higher risk of developing neural tube
defects (Wilson et al.
Although low levels of maternal folic acid--a B vitamin found in green leafy vegetables--is an established risk factor for neural tube
defects, (5) little is known about other environmental factors that may contribute to these birth defects.
Conclusion: Neural tube
defect is identified as major congenital abnormality in this community and consangious relationship being the biggest risk factor associated with it.
31] The observation that neural tube
closure occurs by a multisite process  may also be involved if, for example, different sites are more susceptible to failure of closure in the different sexes.
defects are severe abnormalities of the central nervous system that develop in babies during the first few weeks of pregnancy resulting in malformations of the spine, skull, and brain, which may lead to seizures, intellectual disability, or sight problems, paralysis and a variety of urological and neurological complications.