Neural Crest

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Neural crest

A strip of ectodermal material in the early vertebrate embryo inserted between the prospective neural plate and epidermis. After closure of the neural tube the crest cells migrate into the body and give rise to parts of the neural system: the main part of the visceral cranium, the mesenchyme, the chromaffin cells, and pigment cells. The true nature of the neural crest eluded recognition for many years because this primary organ has a temporary existence; its cells and derivatives are difficult to analyze when dispersed throughout the body. The fact that mesenchyme arises from this ectodermal organ was directly contrary to the doctrine of the specificity of the germ layers.

Neural crest no doubt exists, with similar qualities, in all vertebrate groups, including the cyclostomes. It has been most thoroughly studied in amphibians and the chick. See Germ layers

Neural Crest


the fold of ectoderm that borders the neural, or medullary, plate during neurulation in chordates and man. The cells of the neural crest become distributed over the neural tube after neurulation, forming the ganglionic primordia. The neural crest gives rise to the spinal and sympathetic ganglia, the visceral skeleton, the pigment cells, and the connective tissue layer of the skin.

neural crest

[′nu̇r·əl ′krest]
Ectoderm composing the primordium of the cranial, spinal, and autonomic ganglia and adrenal medulla, located on either side of the neural tube.
References in periodicals archive ?
Con el objetivo de obtener informacion actual acerca de las similitudes moleculares entre los procesos de migracion de las CCN y la metastasis, asi como de las moleculas y las vias de senalizacion que son comunes tanto en las celulas cancerosas como en aquellas provenientes de la cresta neural, se buscaron en las bases de datos PubMed-Medline y Scholar Google, los terminos MeSH neural crest cells, tumor progression, cancer y metastasis, cruzando el termino neural crest cells con los demas por medio del operador booleano AND.
Cephalic neural crest cells and the evolution of craniofacial structures in vertebrates: morphological and embryological significance of the premandibular-mandibular boundary.
Adhesion and migration of avian neural crest cells on fibronectin require the cooperating activities of multiple integrins of the (beta)1 and (beta)3 families.
The appearance of neural crest cells has been intimately linked to the evolution of predation in vertebrates and invention of the "new head" (Gans and Northcutt, 1983; Glenn Northcutt, 2005; Northcutt, 2005).
Work done by a research team in the School of Medicine at the University of California, Riverside, addresses these problems by providing a robust, fast, simple and trackable method to generate neural crest cells.
The hormone's action may also impair neural crest cell movement and could be the ultimate source of the domestication traits, she says.
Previously, the same research team produced customized neural crest cells by first reprogramming patient skin cells into induced pluripotent stem (iPS) cells, which are similar to embryonic stem cells in their ability to become any of a broad array of cell types.
The teratogenecity of RA is manifested primarily by arresting the migration of cranial neural crest cells (CNCC), to their destined tissues, including to the pharyngeal arches.
The identity of the cells was further confirmed by lineage tracing experiments, where the reprogrammed cells were implanted in chicken embryos and acted just as neural crest cells do.
March 15, 2017 -- Researchers have demonstrated that adult skin cells can be converted into neural crest cells (a type of stem cell) without any genetic modification, and that these stem cells can yield other cells that are present in the spinal cord and the brain.
sup][12],[13] It is well known that neural crest cells (NCCs) are a major element in cardiovascular development.
Neuroblastoma is an embryonal cancer of childhood arising from immature neural crest cells of the sympathetic nervous system.