Neural Crest

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Neural crest

A strip of ectodermal material in the early vertebrate embryo inserted between the prospective neural plate and epidermis. After closure of the neural tube the crest cells migrate into the body and give rise to parts of the neural system: the main part of the visceral cranium, the mesenchyme, the chromaffin cells, and pigment cells. The true nature of the neural crest eluded recognition for many years because this primary organ has a temporary existence; its cells and derivatives are difficult to analyze when dispersed throughout the body. The fact that mesenchyme arises from this ectodermal organ was directly contrary to the doctrine of the specificity of the germ layers.

Neural crest no doubt exists, with similar qualities, in all vertebrate groups, including the cyclostomes. It has been most thoroughly studied in amphibians and the chick. See Germ layers

Neural Crest


the fold of ectoderm that borders the neural, or medullary, plate during neurulation in chordates and man. The cells of the neural crest become distributed over the neural tube after neurulation, forming the ganglionic primordia. The neural crest gives rise to the spinal and sympathetic ganglia, the visceral skeleton, the pigment cells, and the connective tissue layer of the skin.

neural crest

[′nu̇r·əl ′krest]
Ectoderm composing the primordium of the cranial, spinal, and autonomic ganglia and adrenal medulla, located on either side of the neural tube.
References in periodicals archive ?
The effect of these perturbations was assessed by in situ hybridization with probes against neural crest specifier genes (markers of morphologically recognizable bona fide neural crest cells, such as SoxE or FoxD family members), but also against other border specifiers expressed in the dorsal neural tube at the time when neural crest progenitors emerge (Fig.
Moreover, although our results suggest that neural crest derivatives may be highly sensitive and excellent markers of the disruptive actions of environmental estrogens, these toxicants appear more likely to interfere with factors that regulate the later differentiation of neural crest cells rather than those that control their early induction.
Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype.
Neural crest cells migrating from dorsal neural tubes are also involved in myotome formation: Migrating neural crest cells come across the dorsomedial lip of the dermomyotome, and neural crest cell-expressing Delta1 is transiently able to activate Notch1 in the dermomyotome, resulting in conversion of Pax3/7(+) myogenic progenitor cells into MyoD/Myf5(+) myotomal myoblasts [30, 31].
RIVERSIDE, Calif., February 3, 2016 -- Neural crest cells arise early in the development of vertebrates, migrate extensively through the embryo, and differentiate to give rise to a wide array of diverse derivatives.
RIVERSIDE, Calif, February 3, 2016 -- Neural crest cells arise early in the development of vertebrates, migrate extensively through the embryo, and differentiate to give rise to a wide array of diverse derivatives.
The wandering cells are neural crest cells, which appear early in development in vertebrate embryos.
INTRODUCTION: Primitive neuroectodermal tumour is a malignant small round cell malignancy of presumably primitive, neuroectodermal tissue or pluripotential, migratory neural crest cells arising from the soft tissue or bone, predominantly in older children and adults.
Muscle formation in the target stem cells occurred only when the NOTCH pathway was triggered briefly by the migrating neural crest cells.
Specific populations of neural crest cells that contribute to the skeletal elements in the head have been identified in mapping studies (Couly et al., 1993; Schilling and Kimmel, 1994).
The assay models migration inhibition of neural crest cells during development, which may be affected by unspecific toxicants or by specific inhibitors.
Recently, neural crest cells (NCCs) have been reported as an effective pathway to induce mesenchymal progenitors, as the resulting cells appear to have high potential for differentiation into osteocytes and chondrocytes [30-33].