Neural Crest

(redirected from Neural crest cells)
Also found in: Dictionary, Thesaurus, Medical.

Neural crest

A strip of ectodermal material in the early vertebrate embryo inserted between the prospective neural plate and epidermis. After closure of the neural tube the crest cells migrate into the body and give rise to parts of the neural system: the main part of the visceral cranium, the mesenchyme, the chromaffin cells, and pigment cells. The true nature of the neural crest eluded recognition for many years because this primary organ has a temporary existence; its cells and derivatives are difficult to analyze when dispersed throughout the body. The fact that mesenchyme arises from this ectodermal organ was directly contrary to the doctrine of the specificity of the germ layers.

Neural crest no doubt exists, with similar qualities, in all vertebrate groups, including the cyclostomes. It has been most thoroughly studied in amphibians and the chick. See Germ layers

Neural Crest


the fold of ectoderm that borders the neural, or medullary, plate during neurulation in chordates and man. The cells of the neural crest become distributed over the neural tube after neurulation, forming the ganglionic primordia. The neural crest gives rise to the spinal and sympathetic ganglia, the visceral skeleton, the pigment cells, and the connective tissue layer of the skin.

neural crest

[′nu̇r·əl ′krest]
Ectoderm composing the primordium of the cranial, spinal, and autonomic ganglia and adrenal medulla, located on either side of the neural tube.
References in periodicals archive ?
Skin cells from a person with a genetic disease of the nervous system can be reprogrammed into neural crest cells.
Neural crest cells and other embryonic cells called placode cells display just the sort of run-and-chase behavior that enables effective migration, Mayor said.
A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells.
The BMPs play an important role in the migration of neural crest cells for the formation of the 3 components of the jaw (thin blue arrows).
The neural crest cells also studied widely under experimental methods to enlighten their role and surface interactions.
Editor Trainor offers this detailed text on neural crest cells divided into three sections.
It begins in neural crest cells that are involved in the development of the nervous system and other tissues.
2,3) The tissues that produce craniofacial structures in vertebrates originate from ectoderm, mesoderm, endoderm, and cranial neural crest cells (CrnNC).
Laryngeal paragangliomas are rare neoplasms that originate in the neural crest cells of the laryngeal paraganglia.
Neural crest cells manifest early in the development of a vertebrate embryo.