Neuraminic Acid

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neuraminic acid

[¦nu̇r·ə¦min·ik ′as·əd]
(biochemistry)
C9H17NO8 An amino acid, the aldol condensation product of pyruvic acid and N-acetyl-D-mannosamine, regarded as the parent acid of a family of widely distributed acyl derivatives known as sialic acids.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Neuraminic Acid

 

5-amino-3, 5-deoxy-D-glycero-n-galac-to-2-nonulosonic acid, a natural compound occurring as N- and O-acyl derivatives (sialic acids) in all the organs and tissues of animals and in certain microorganisms. The acyl derivatives of neuraminic acid (the most common of which are N-acetyl and N-glycolyl neuraminic acids) are constituents of natural glycolipids and glycoproteins, where they are bonded to monosaccharide radicals. The neuraminic acid radical is split off from the glycolipid and glycoprotein molecules under the action of the specific enzyme neuraminidase or dilute acids, thereby substantially altering the physicochemical and biological properties of the molecules. Certain pathological conditions (cancer, tuberculosis, mental disorders) induce a marked increase in the neuraminic acid content of fluids and tissues in the human body. In glycolipid form, neuraminic acid takes part in the fixation of certain viruses and neurotoxins in animal organisms. The biosynthesis of neuraminic acid is effected in the presence of hexosa-mine derivatives and pyruvic acid.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
[19] conducted the detection of several neuraminic acids (N-acetyl-D-galactosamine, Nacetyl-D-glucosamine, and N-acetylneuraminate) and confirmed that they are the main components for sialic acid from genuine EBN.
Blood was collected by heart puncture, serum separated, and used to estimate serum sialic acid by thiobarbituric acid assay (Skoza and Mohos 1976) with N-acetyl neuraminic acid as standard.
HN also acts as an enzyme (NA, neuraminidase or sialidase) that removes sialic acid (neuraminic acid) moieties from viral progeny to prevent self-aggregation, favoring the release of virions from the cell.
The neuraminidase breaks links in neuraminic acid located on the surface of host cells helping the bacterium invade tissues.
It contains a unique, polymerized glyconutrient ingredient that incorporates all eight essential monosaccharides (glucose, xylose, fucose, N-acetyl galactosmine, mannose, N-Acetyl glucosamine, N-acetyl neuraminic acid and galactose) in a single, non-branched polysaccharide chain.
Primary structure and expression analysis of human UDP-N-acetyl-glucosamine-2-epimerase/ N-acetylmannosamine kinase, the bifunctional enzyme in neuraminic acid biosynthesis.
Supplements that may be useful in achieving these ends include N-acetyl glucosamine, N-acetyl neuraminic acid (sialic acid), D-mannose, L-glutamine, L-glutamic acid HC1, inulin, quercitin, methylsulfonylmethane (MSM), Manapol[R], and digestive enzyme formulations, with, or without, hydrochloric acid.
Dr Sweet said the new generation of drugs was designed to work against all kinds of flu viruses by targeting a protein called N-acetyl neuraminic acid.
Sialic acid is a generic term for a family of acetylated derivatives of neuraminic acid, which is an essential component of glycoproteins and glycolipids.
Their chemistry varies; the Sia family, representing about 50 members, are all derivatives of the 5-amino 2- keto-3-deoxy nononic acid, the "neuraminic acid" (Fig.
Furthermore, binding of ML-I to neuraminic acid containing glycolipids like alpha2,6 sialylated neolacto gangliosides will be discussed.
The N activity disrupts neuraminic acid in the receptors of the host cells, allowing release of newly propagated virus.