Neuraminic Acid

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neuraminic acid

[¦nu̇r·ə¦min·ik ′as·əd]
C9H17NO8 An amino acid, the aldol condensation product of pyruvic acid and N-acetyl-D-mannosamine, regarded as the parent acid of a family of widely distributed acyl derivatives known as sialic acids.

Neuraminic Acid


5-amino-3, 5-deoxy-D-glycero-n-galac-to-2-nonulosonic acid, a natural compound occurring as N- and O-acyl derivatives (sialic acids) in all the organs and tissues of animals and in certain microorganisms. The acyl derivatives of neuraminic acid (the most common of which are N-acetyl and N-glycolyl neuraminic acids) are constituents of natural glycolipids and glycoproteins, where they are bonded to monosaccharide radicals. The neuraminic acid radical is split off from the glycolipid and glycoprotein molecules under the action of the specific enzyme neuraminidase or dilute acids, thereby substantially altering the physicochemical and biological properties of the molecules. Certain pathological conditions (cancer, tuberculosis, mental disorders) induce a marked increase in the neuraminic acid content of fluids and tissues in the human body. In glycolipid form, neuraminic acid takes part in the fixation of certain viruses and neurotoxins in animal organisms. The biosynthesis of neuraminic acid is effected in the presence of hexosa-mine derivatives and pyruvic acid.

References in periodicals archive ?
Furthermore, binding of ML-I to neuraminic acid containing glycolipids like alpha2,6 sialylated neolacto gangliosides will be discussed.
It contains a unique, polymerized glyconutrient ingredient that incorporates all eight essential monosaccharides (glucose, xylose, fucose, N-acetyl galactosmine, mannose, N-Acetyl glucosamine, N-acetyl neuraminic acid and galactose) in a single, non-branched polysaccharide chain.
Primary structure and expression analysis of human UDP-N-acetyl-glucosamine-2-epimerase/ N-acetylmannosamine kinase, the bifunctional enzyme in neuraminic acid biosynthesis.
meningitidis isolates in Canada bore an [alpha] 2-9 N-acetyl neuraminic acid (serogroup C) capsule, but recent epidemics of meningococcal disease, particularly in Africa, have been associated with ST11 meningococci bearing the W135 capsule.
Dr Sweet said the new generation of drugs was designed to work against all kinds of flu viruses by targeting a protein called N-acetyl neuraminic acid.
Sialic acids are derived from neuraminic acid whose main derivative is N-acetylneuraminic acid, which is generally used as a synonym for sialic acid (Ledeen and Yu 1976).
The "tau" isoform of trf is the neuraminidase-induced product that has lost one of its four neuraminic acid moieties and occurs in the cerebrospinal fluid (CSF), perilymph (4), and ocular fluids (5) but rarely in the serum.
For example, enzymatic methods appear to be more accurate than colorimetric methods (16,21), but neither method can differentiate among different neuraminic acids; HPAE-PAD, used mainly for the analysis of sialic acids released from glycoconjugates, can reduce the possibility of interferences by relatively long gradient separations.
N-acetyl neuraminic acid and papain were obtained from Sisco Research Laboratory (Bombay).