Neuraminic Acid

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neuraminic acid

[¦nu̇r·ə¦min·ik ′as·əd]
(biochemistry)
C9H17NO8 An amino acid, the aldol condensation product of pyruvic acid and N-acetyl-D-mannosamine, regarded as the parent acid of a family of widely distributed acyl derivatives known as sialic acids.

Neuraminic Acid

 

5-amino-3, 5-deoxy-D-glycero-n-galac-to-2-nonulosonic acid, a natural compound occurring as N- and O-acyl derivatives (sialic acids) in all the organs and tissues of animals and in certain microorganisms. The acyl derivatives of neuraminic acid (the most common of which are N-acetyl and N-glycolyl neuraminic acids) are constituents of natural glycolipids and glycoproteins, where they are bonded to monosaccharide radicals. The neuraminic acid radical is split off from the glycolipid and glycoprotein molecules under the action of the specific enzyme neuraminidase or dilute acids, thereby substantially altering the physicochemical and biological properties of the molecules. Certain pathological conditions (cancer, tuberculosis, mental disorders) induce a marked increase in the neuraminic acid content of fluids and tissues in the human body. In glycolipid form, neuraminic acid takes part in the fixation of certain viruses and neurotoxins in animal organisms. The biosynthesis of neuraminic acid is effected in the presence of hexosa-mine derivatives and pyruvic acid.

References in periodicals archive ?
Additionally, dogs and humans express a similar diversity of sialic acid variants and linkages, which have been demonstrated to be important determinants of IAV infection and host range (26), including N-acetyl neuraminic acid and both the [alpha]2-3 and [alpha]2-6 linkages (27,28).
Hayward, USA) Properties K2 K10 Dextrin - + D-Maltose + + D-Trehalose - + D-Cellobiose - + Gentiobiose - + Sucrose - + D-Turanose - + Stachyose - - pH 6 + + pH 5 - + D-Raffinose - - D-Lactose - - D -Melibiose - + [beta]-Methyl-D-Glucoside - + D-Salicin - + N-Acetyl-d-Glucosamine - + N-Acetyl-b-d-Mannosamine - - N-Acetyl-d-Galactosamine - - N-Acetyl Neuraminic Acid - - 1% NaCl + + 4% NaCl + + 8% NaCl ND + a-d-Glucose - + D-Mannose - + D-Fructose + + D-Galactose - - 3-Methyl Glucose - - D-Fucose - - L-Fucose - - L-Rhamnose - - Inosine - - 1% Sodium Lactate + + Fusidic Acid - - D-Serine - - D-Sorbitol - + D-Mannitol - + D-Arabitol - - myo-Inositol - + Glycerol - + D-Glucose-6-P[O.
From over 30 acetylated derivatives of neuraminic acid, N-acetylneuraminic acid (referred to as sialic acid) is the most common in humans.
N-Acetyl neuraminic acid was purchased from Sisco Research Laboratory (Mumbai, India).
Sialic acid comprises of a family of acetylated derivatives of neuraminic acid, which act as acute phase proteins and elevated in numerous inflammatory conditions like diabetes, cancer, and renal diseases.
In SP-HUS, bacterial neuraminidase is thought to cleave N-acetyl neuraminic acid from the surface of red blood cells, platelets, and endothelium, exposing the Thomsen-Friedenreich (T) cryptantigen.
Sialic acid, which is a derivative of acetyl neuraminic acid, attached to non-reducing residues of carbohydrate chain of glycoproteins and glycolipids is found to be elevated in alcohol abuse (8).
GalNAc-GD1a is branched structure containing two neuraminic acid groups at 2 and 4 positions.
1] N-acetyl neuraminic acid (NANA), which assures that all of the cnidocyte/supporting cell complexes (CSCCs) are maximally predisposed to discharge in response to the contact stimuli of the probes.
The neuraminidase breaks links in neuraminic acid located on the surface of host cells helping the bacterium invade tissues.
It contains a unique, polymerized glyconutrient ingredient that incorporates all eight essential monosaccharides (glucose, xylose, fucose, N-acetyl galactosmine, mannose, N-Acetyl glucosamine, N-acetyl neuraminic acid and galactose) in a single, non-branched polysaccharide chain.
Primary structure and expression analysis of human UDP-N-acetyl-glucosamine-2-epimerase/ N-acetylmannosamine kinase, the bifunctional enzyme in neuraminic acid biosynthesis.