Neuraminic Acid


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neuraminic acid

[¦nu̇r·ə¦min·ik ′as·əd]
(biochemistry)
C9H17NO8 An amino acid, the aldol condensation product of pyruvic acid and N-acetyl-D-mannosamine, regarded as the parent acid of a family of widely distributed acyl derivatives known as sialic acids.

Neuraminic Acid

 

5-amino-3, 5-deoxy-D-glycero-n-galac-to-2-nonulosonic acid, a natural compound occurring as N- and O-acyl derivatives (sialic acids) in all the organs and tissues of animals and in certain microorganisms. The acyl derivatives of neuraminic acid (the most common of which are N-acetyl and N-glycolyl neuraminic acids) are constituents of natural glycolipids and glycoproteins, where they are bonded to monosaccharide radicals. The neuraminic acid radical is split off from the glycolipid and glycoprotein molecules under the action of the specific enzyme neuraminidase or dilute acids, thereby substantially altering the physicochemical and biological properties of the molecules. Certain pathological conditions (cancer, tuberculosis, mental disorders) induce a marked increase in the neuraminic acid content of fluids and tissues in the human body. In glycolipid form, neuraminic acid takes part in the fixation of certain viruses and neurotoxins in animal organisms. The biosynthesis of neuraminic acid is effected in the presence of hexosa-mine derivatives and pyruvic acid.

References in periodicals archive ?
From over 30 acetylated derivatives of neuraminic acid, N-acetylneuraminic acid (referred to as sialic acid) is the most common in humans.
A deaminated derivative of neuraminic acid is 2-keto 3- deoxy nononic acid (Kdn) which was found in glycans from animals and microorganisms.
N-Acetyl neuraminic acid was purchased from Sisco Research Laboratory (Mumbai, India).
In SP-HUS, bacterial neuraminidase is thought to cleave N-acetyl neuraminic acid from the surface of red blood cells, platelets, and endothelium, exposing the Thomsen-Friedenreich (T) cryptantigen.
Sialic acid, which is a derivative of acetyl neuraminic acid, attached to non-reducing residues of carbohydrate chain of glycoproteins and glycolipids is found to be elevated in alcohol abuse (8).
It contains a unique, polymerized glyconutrient ingredient that incorporates all eight essential monosaccharides (glucose, xylose, fucose, N-acetyl galactosmine, mannose, N-Acetyl glucosamine, N-acetyl neuraminic acid and galactose) in a single, non-branched polysaccharide chain.
meningitidis isolates in Canada bore an [alpha] 2-9 N-acetyl neuraminic acid (serogroup C) capsule, but recent epidemics of meningococcal disease, particularly in Africa, have been associated with ST11 meningococci bearing the W135 capsule.
A rapid and sensitive procedure for determination of 5-N-acetyl neuraminic acid in lipopolysaccharides of Haemophilus influenzae: a survey of 24 non-typeable H.
Supplements that may be useful in achieving these ends include N-acetyl glucosamine, N-acetyl neuraminic acid (sialic acid), D-mannose, L-glutamine, L-glutamic acid HC1, inulin, quercitin, methylsulfonylmethane (MSM), Manapol[R], and digestive enzyme formulations, with, or without, hydrochloric acid.
Dr Sweet said the new generation of drugs was designed to work against all kinds of flu viruses by targeting a protein called N-acetyl neuraminic acid.
Hemolysis depends on the sialic acid-binding activity of limulin, because sialylated glycoconjugates, such as fetuin, and the sialic acids N-acetyl neuraminic acid and colominic acid inhibit hemolysis.
Furthermore, binding of ML-I to neuraminic acid containing glycolipids like alpha2,6 sialylated neolacto gangliosides will be discussed.