Neuraminic Acid


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neuraminic acid

[¦nu̇r·ə¦min·ik ′as·əd]
(biochemistry)
C9H17NO8 An amino acid, the aldol condensation product of pyruvic acid and N-acetyl-D-mannosamine, regarded as the parent acid of a family of widely distributed acyl derivatives known as sialic acids.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Neuraminic Acid

 

5-amino-3, 5-deoxy-D-glycero-n-galac-to-2-nonulosonic acid, a natural compound occurring as N- and O-acyl derivatives (sialic acids) in all the organs and tissues of animals and in certain microorganisms. The acyl derivatives of neuraminic acid (the most common of which are N-acetyl and N-glycolyl neuraminic acids) are constituents of natural glycolipids and glycoproteins, where they are bonded to monosaccharide radicals. The neuraminic acid radical is split off from the glycolipid and glycoprotein molecules under the action of the specific enzyme neuraminidase or dilute acids, thereby substantially altering the physicochemical and biological properties of the molecules. Certain pathological conditions (cancer, tuberculosis, mental disorders) induce a marked increase in the neuraminic acid content of fluids and tissues in the human body. In glycolipid form, neuraminic acid takes part in the fixation of certain viruses and neurotoxins in animal organisms. The biosynthesis of neuraminic acid is effected in the presence of hexosa-mine derivatives and pyruvic acid.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Our basic knowledge on the occurrence and complicated structure of neuraminic acid itself and the various sialic acid forms and the numerous metabolic reactions and genes involved in the synthesis, modification, transfer, and breakdown, and principal (patho-physiological) functions of Sia was acquired since the 1940s.
Blood was collected by heart puncture, serum separated, and used to estimate serum sialic acid by thiobarbituric acid assay (Skoza and Mohos 1976) with N-acetyl neuraminic acid as standard.
A naturally occurring deaminated neuraminic acid, 3-deoxy-D-glycero-D-galacto-nonulosonic acid (KDN).
N-acetyl neuraminic acid is an important immunomodulating carbohydrate that plays a very important role in the proper development of the lining of the small intestine from the standpoint of both its digestive and immune functions.
Sialic acid is a generic term for a family of acetylated derivatives of neuraminic acid, which is an essential component of glycoproteins and glycolipids.
Furthermore, binding of ML-I to neuraminic acid containing glycolipids like alpha2,6 sialylated neolacto gangliosides will be discussed.
Neuraminic acid, N-acetylaspartic acid, and the N-acetyl groups in glycoproteins in urine from healthy controls are known to contribute to the resonances in this area (10).
The hemolytic activity of purified limulin was dependent on its SA-recognition capabilities, because limulin-mediated hemolysis was abolished by desialylation of the target erythrocytes with V cholerae neuraminidase, or by inclusion of 9 [[micro]meter] fetuin in the incubation medium, and was reduced 50% by 0.1 M N-acetyl neuraminic acid.
Sialic acids are derived from neuraminic acid whose main derivative is N-acetylneuraminic acid, which is generally used as a synonym for sialic acid (Ledeen and Yu 1976).
N-acetyl neuraminic acid and papain were obtained from Sisco Research Laboratory (Bombay).
The [[beta].sub.2]-transferrin ([beta]2Tr) r-fraction, or asialotransferrin, is a brain-specific variant of transferrin that lacks neuraminic acid. It therefore can be distinguished from serum transferrin by electrophoretic procedures and used to detect CSF rhinorrhea (3, 4).
The spectrum of free neuraminic acid storage disease in childhood: clinical, morphological and biochemical observations in three non-Finnish patients.