Neuroblasts


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Neuroblasts

 

embryonic nerve cells that are converted to mature nerve cells, or neurons, during the course of development. In contrast to neurons, neuroblasts partially retain the capacity to divide. In mammals maturation of neuroblasts is completed shortly after birth. For this reason, no new neurons are formed during the subsequent life of the organism. Neuroblastomas are tumors that can arise during the malignant degeneration of neuroblasts.

References in periodicals archive ?
We previously reported that GALNT13 is highly expressed (12 times higher) in metastatic neuroblasts than in primary tumors (19).
Briefly, human IGR-N-91 neuroblasts derived from an involved BM collected from a stage 4 disease >1-year-old NB patient were injected subcutaneously into nude mice to give rise to a stage 4 disease.
To this end, we compared the gene expression profiles of metastatic-derived neuroblasts (BM and Myoc) with stage 4 disease profiles from the IGR-N-91 experimental human NB model (9,10) using Agilent long oligonucleotide arrays with 8 arrays (see the section "Microarray Experiments", above).
In this model, although established metastatic neuroblasts exhibit a similar MYCN amplification compared with stage 4 disease-derived neuroblasts, a considerably higher MYCN expression is observed that is consistent with their aggressive biological behavior (10).
The higher differentially up-regulated gene in this set is GALNTI3 (12-fold higher in metastatic neuroblasts compared with primary tumor, P = 9.
To determine whether GALNTI3 might be a potential marker for NB dissemination, we tested for malignant neuroblasts in BM from patients with various stages of NB by measuring GALNTI3 expression.
However, in spite of specific GALNTI3 mRNA detection, the lower limit of the detection of analyses appears less than optimal, and we conclude, therefore, that GALNTI3 expression will be suitable only for detection of malignant neuroblasts at diagnosis or relapse.
Localization of epidermal growth factor receptors and putative neuroblasts in human subependymal zone.
Expression of unphosphorylated class III [Beta]-tubulin isotype in neuroepithelial cells demonstrates neuroblast commitment and differentiation.