Neuroblasts


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Neuroblasts

 

embryonic nerve cells that are converted to mature nerve cells, or neurons, during the course of development. In contrast to neurons, neuroblasts partially retain the capacity to divide. In mammals maturation of neuroblasts is completed shortly after birth. For this reason, no new neurons are formed during the subsequent life of the organism. Neuroblastomas are tumors that can arise during the malignant degeneration of neuroblasts.

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Until now, many researchers have been trying to find new medical plants and their components, which can promote neurogenesis in the neurogenic regions, as a potential therapeutic agent of neurodegenerative diseases and many studies have demonstrated that some plant extracts and their components have the capacity to promote neurogenesis.[26],[27] Although some researchers recently showed that extracts of plants in the family Umbelliferae including Oenanthe javanica and Angelica sinensis improved cell proliferation and neuroblast differentiation in the SGZ of the hippocampal DG,[28],[29] neurogenic effects of GLein the brainhave not yet been investigated.
At D3, there were no significant differences in neuroblast density between PB-MNC+, PB-MNC, and PBS groups (52,262 [+ or -] 14,825 [micro][m.sup.2]; 47,579 [+ or -] 14,099 [micro][m.sup.2]; and 57,225 [+ or -] 21,634 [micro][m.sup.2], resp.) or in the migration distance of DCX+ cells toward the ischemic area (825.6 [+ or -] 177.4 [micro]m; 618.8 [+ or -] 184.5 [micro]m; and 765 [+ or -] 135.5 [micro]m, resp.) (N = 4 - 5) (Figure 7).
In addition, a significant decrease in the number of neuroblasts (DCX-positive immature neurons) in the YAC128 hippocampal DG was observed at 6 months of age.
A single tumor may contain a wide range of cellular phenotypes characteristic of this transient embryonic structure, in particular neuroblasts, melanocytes, and nonneuronal cells such as Schwann, perineurial, or satellite cells.
Neuroblasts were positive for vimentin and S100 (Figure 1E), specifically in the nucleus and cell membrane, and exhibited discrete positive staining for NSE in the cytoplasm (Figure 1D).
There are no neuroblasts seen in the current specimen, which was submitted entirely (Figure 5).
Type A cells are proliferating neuroblasts that form chains to migrate, while type B cells are similar to astrocytes morphologically [9].
The migration of neuroblasts that will form the myenteric plexus begins in small intestines at I.U.
Stress by noise produces differential effects on the proliferation rate of radial astrocytes and survival of neuroblasts in the adult subgranular zone.
Ibuprophen attenuates the inflammatory response and allows formation of migratory neuroblasts from grafted stem cells after traumatic brain injuries.
Neuroblastoma is an embryonic malignancy arising from the neuroblasts which show tremendous clinical heterogeneity.
PHOX2B was positive in neuroblasts and ganglion cells and showed reactivity in 75% of undifferentiated NBs, 100% of poorly differentiated NBs, and 96% of differentiating NB/ganglioneuroblastomas.