While, in specific classification of CMT, carcinoma with neuroendocrine differentiation, some neuroendocrine cells
were positive as well as in luminal epithelial cells.
Diffuse idiopathic pulmonary neuroendocrine cell
hyperplasia (DIPNECH) is a rare primary disorder that is detected incidentally without preexisting chronic lung disease and is considered to be neuroendocrine cell
proliferation, often accompanied by constrictive obliterative bronchiolitis.
Unlike normal NETs, these tumors contain co-existing mucinladen goblet-shaped cells and neuroendocrine cells
arranged in nests or clusters, with weak or partial immunopositivity for neuroendocrine markers (7).
This may be due to high tumor level neuroendocrine cell
products which stimulate growth and lack androgen receptors in neuroendocrine cells
, subsequently with low therapy response (3,4).
There are tumor markers that have been identified as being expressed in these neuroendocrine cells
, including TTF-1, which is a nuclear transcription factor regulator that is usually expressed in lung or thyroid tissue but can be seen in these tumors arising from other organs as well.
NETs are composed by neuroendocrine cells
which are scattered through the mucosa of the gastrointestinal tract.
Pheochromocytoma/paraganglioma is a rare tumor arising from neuroendocrine cells
. Increasing numbers of susceptibility genes have been identified, and approximately 1/3rd of cases have germline mutation.
Neuroendocrine tumors (NETs) originate from neuroendocrine cells
of the diffuse endocrine system.
 Carcinoid tumours are slow-growing tumours, originating from neuroendocrine cells
which are classified into four categories: i) Insular; ii) Trabecular; iii) Strumal; and iv) Mucinous types.
Bonkhoff, "Neuroendocrine cells
in benign and malignant prostate tissue: morphogenesis, proliferation, and androgen receptor status," The Prostate.
are one of the largest groups of hormone-producing cells in the body.
The origin of PHNET is still unknown, but possible and plausible theories include transformation of liver stem cells; neuroendocrine differentiation of ectopic adrenal tissue or of heterotopic pancreatic tissue in the liver; and transformation of neuroendocrine cells
of the intrahepatic biliary ductal epithelium .