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In the case of plaques, concentrating degenerative neurofibrils to the core substance were stained by such sliver stains.
These damaging plaques disrupt the neurofibrils in the brain by causing them to tangle up.
Also, insoluble aggregates of the amyloid beta-peptide (A[beta]) and neurofibrils composed of Tau protein are found in AD [30,31] and hyperphosphorylated Tau aggregation in demyelination areas in MS [32].