neurofibrillary tangle


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neurofibrillary tangle

[‚nu̇·rō‚fīb·rə‚ler·ē ′taŋ·gəl]
(pathology)
The accumulation of twisted protein filaments (neurofibrils) within neurons of the cerebral cortex; a characteristic pathological feature found in the brains of Alzheimer's disease patients.
References in periodicals archive ?
They looked for presence of TDP-43 and tau neurofibrillary tangle burden in the hippocampus and the lateral temporal cortex, an area affected in Alzheimer's disease.
PKC Isozymes Regulate Amyloid Plaque and Neurofibrillary Tangle Metabolism
Sex differences were not seen in the correlation between APOE and ?-amyloid 42, neuritis plaque burden, or neurofibrillary tangle burden.
In AD brains, tau moves from the axons to the somatodendritic compartment of neurons, where it forms hyperphosphorylated, filamentous aggregates described as neurofibrillary tangles. Postmortem studies report greater neurofibrillary tangle pathology in AD patients with a lifetime history of depression compared with those without such a history (8), and more severe cortical neurofibrillary tangle pathology is found in the brains of AD subjects who suffered from comorbid depression (9).
Although they cannot be detected prior to autopsy, characteristic pathologic features of this disease include neurofibrillary tangle and plaque formation and changes in oxidative and inflammatory processes as well as cholinergic neurotransmission.
Others favor different suspects, such as the protein that lies at the base of the neurofibrillary tangle or calcium ions, which figure importantly in many aspects of cell function.
Postmortem studies of human brains and neuroimaging studies have suggested that the disease, especially the neurofibrillary tangle pathology, begins in the entorhinal cortex, which plays a key role in memory.
This includes [18F]-MK-6240, a tau ligand currently being evaluated as a potential Positron Emission Tomography imaging agent for quantifying the brain burden of neurofibrillary tangle pathology in people with AD.
The truncated tau (delta tau, aka TauC3 fragment) has higher rates and extents of polymerisation in-vitro versus wild-type full-length tau, indicating a role for tau truncation in neurofibrillary tangle formation.
5, 2019 (HealthDay News) -- White matter rarefaction, arteriolosclerosis, and dorsolateral frontal cortex (DLFC) neurofibrillary tangles (NFTs) are independently associated with dementia among older men who played football and had chronic traumatic encephalopathy (CTE), according to a study published online Aug.
Neurofibrillary tangles composed of aggregated tau protein is one of the pathological features of Alzheimer's disease (AD).