Davis, "Neocortical neurofibrillary tangles
correlate with dementia severity in Alzheimer's disease," Archives of Neurology, vol.
Similarly, Bieloschsky silver impregnation revealed no clear pathology in the blank and saline groups, but neurofibrillary tangles
in the treatment group (Fig.
This new ability to see tau neurofibrillary tangles
in vivo "should eventually enable us to more efficiently develop preventive therapies and even treatments for the actual symptoms," he said.
Another vaccine approach against AD has been based on the other pathological marker of the disease as the target antigen, the neurofibrillary tangles
produced by hyperphosphorylation of the Tau protein (11).
(NFTs) in AD brain are consist of paired helical filaments (PHFs), which are mainly composed of hyperphosphorylated tau protein (Maccioni et al.
It is interesting to note the use of also the diagnostic category "diffuse neurofibrillary tangles
with calcification" (DNTC) as a form of progressive dementia characterized by temporal or frontotemporal atrophy with neuronal loss and astrocytosis, neurofibrillary tangles
, and Fahr-type calcification, but no senile plaques in the cerebral cortex [8-14].
Other distinct clinicopathologic disorders in the scope of Hallervorden-Spatz syndrome include dementia, tetraparesis, neurofibrillary tangles
, retinitis pigmentosa and acanthocytosis with or without lipid abnormalities, including hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, pallidal degeneration .
AD is a neurodegenerative process in which amyloid protein forms plaques and misprocessed tau protein forms neurofibrillary tangles
in the brain, disrupting neural function.
The presence of excess amount of A[sz] deposits and neurofibrillary tangles
, NFTs, 5-6 comprising of hyperphosphorylated Tau proteins are the hallmarks of an AD brain.1
Two features in the brain, abnormal clumps (senile plaques) and tangled bundles of fibers (neurofibrillary tangles
), are known to characterize AD, but there is little consensus on the link between these features and the underlying roots of the disease.
The major pathologic findings in the AD brain at autopsy are amyloid plaques (extracellular), neurofibrillary tangles
(intracellular), and the loss of synaptic connections.
"The neuropathological diagnosis in the participants who did not meet pathological criteria for AD included dementia with Lewy bodies, hippocampal sclerosis, Parkinson's disease, subcortical microscopic infarct, mesial temporal lobe neurofibrillary tangles
, neurofibrillary tangles
with argyrophilic grains and glial tauopathy, and no neuropathology," the authors wrote.