neurofilament

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neurofilament

[‚nu̇·rō′fil·ə·mənt]
(physiology)
A type of intermediate filament, composed of three polypeptides (NF-L, NF-M, and NF-H), that helps support and strengthen the axons of nerve cells.
References in periodicals archive ?
In the case of Al-maltolate treated aged rabbits, amyloid precursor protein (APP), A[beta], neurofilament protein like unphosphorylated tau, ([alpha]--1 antichymotrypsin and ubiquitin are observed, while, in AD in addition to the above features neurofilament protein is hyperphoshorylated (40,43).
Characterization of a cyclic nucleotide- and calcium-independent neurofilament protein kinase activity in axoplasm from the squid giant axon.
The nature of the myelinated nerve fascicles was well demonstrated by trichrome (figure 2, E) and Bielschowsky's staining (figure 2, F), as well as by immunohistochemical staining for neurofilament protein (figure 2, G).
Differential expression of two neuronal intermediate-filament proteins, peripherin and the low-molecular-mass neurofilament protein (NF-L), during development of the rat.
18) Because neurofibromas contain Schwann cells and frequent nerve twigs, we hypothesize that antibodies to neurofilament protein may be supplemental to Melan-A in differentiating neurofibromas from neurotized melanocytic nevi.
We gratefully acknowledge Phil Grant for his gift of neurofilament protein antibodies.
Schwann cell hamartomas express S100 protein in a strong, diffuse pattern with both nuclear and cytoplasmic staining (Figure 3, C), and some of these lesions have rare axons that stain with neurofilament protein.
Neurofilament protein stains show axons to be largely intact.
NN 18, a monoclonal antibody raised to vertebrate neurofilament protein, stained the conical region of B.
14) Intestinal perineuriomas are negative for S100 protein, smooth muscle actin, desmin, caldesmon, CD117 (c-Kit), pancytokeratin, glial fibrillary acidic protein, and neurofilament protein.
We discuss (1) placental alkaline phosphatase, c-Kit, and OCT4 for germinoma, (2) [alpha]-inhibin and D2-40 for capillary hemangioblastoma, (3) phosphohistone-H3 (PHH3), MIB-1/Ki-67, and claudin-1 for meningioma, (4) PHH3, MIB-1/Ki-67, and p53 for astrocytoma, (5) synaptophysin, microtubule-associated protein 2, neurofilament protein, and neuronal nuclei for medulloblastoma, (6) INI1 for atypical teratoid/ rhabdoid tumor, and (7) epithelial membrane antigen for ependymoma.
Other neuronal marker proteins that have been identified in central neurocytoma include neurofilament protein, neuron-associated class III [beta]-tubulin, and microtubule-associated proteins MAP2 and tau.