We have previously found that multiple intermediate neurofilament proteins
specifically coimmunoprecipitate with spinophilin .
The interesting work carried out by Savory and his co-workers on the quantitation of Al in the brain and spinal cord and its effects on neurofilament protein
expression and phosphorylation provided new evidence for the involvement of Al in AD (42).
Clinical and demographic findings can help make distinctions, as can pertinent immunohistochemical reactions to synaptophysin, chromogranin, neuron-specific enolase (NSE), neurofilament protein
(NFP), S-100 protein, keratin, CD45RB, desmin, CD99, and HMB45.
Julien suggests seeking out agents that could block production of the neurofilament protein
, but he and others acknowledge that little has been published on the whole topic.
However, expression of many other markers can be found including NSE, SYNP, chromogranin, CD56, CD57, S-100, and neurofilament protein
. In addition, some tumors have focal positivity for CK.
Schlaepfer, "Disruption of neurofilament network with aggregation of light neurofilament protein
: a common pathway leading to motor neuron degeneration due to Charcot-Marie-Tooth disease-linked mutations in NFL and HSPB1," Human Molecular Genetics, vol.
As a consequence, Jaeger showed in a recently published review that besides CK20 expression neuron-specific-enolase (NSE) and neurofilament protein
(NFP) is specific for Merkel cell carcinoma .
The tumor cells express neuronal markers, such as class III-[beta] tubulin, microtubule associated protein 2 (MAP2), NeuN, and neurofilament protein
. Of note, GFAP may be focally positive, which has been interpreted as reactive astroglia.
Characterization of the phosphorylation sites of the squid (Loligo pealei) high-molecular-weight neurofilament protein
from giant axon axoplasm.
Immunostaining was performed with glial fibrillary acidic protein, neurofilament protein
, S-100, and the proliferation index MIB-1 (Ki-67).
Key words: brain development, chlorpyrifos, glia, myelin basic protein, neurofilament protein
Tokutake, "Presence of neurofilament protein
in Alzheimer's neurofibrillary tangles (ANT).