neurofilament

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neurofilament

[‚nu̇·rō′fil·ə·mənt]
(physiology)
A type of intermediate filament, composed of three polypeptides (NF-L, NF-M, and NF-H), that helps support and strengthen the axons of nerve cells.
References in periodicals archive ?
In the case of Al-maltolate treated aged rabbits, amyloid precursor protein (APP), A[beta], neurofilament protein like unphosphorylated tau, ([alpha]--1 antichymotrypsin and ubiquitin are observed, while, in AD in addition to the above features neurofilament protein is hyperphoshorylated (40,43).
The nature of the myelinated nerve fascicles was well demonstrated by trichrome (figure 2, E) and Bielschowsky's staining (figure 2, F), as well as by immunohistochemical staining for neurofilament protein (figure 2, G).
Differential expression of two neuronal intermediate-filament proteins, peripherin and the low-molecular-mass neurofilament protein (NF-L), during development of the rat.
Neurofilament protein antibody stained almost all cases of neurofibromas (48 of 49; 98%), with occasional cytoplasmic positivity in both nerve twiglike areas and random, single cells; about half of the cases of neurotized melanocytic nevi (25 of 49; 51%) showed occasional cytoplasmic positive staining within random tumor cells.
The ganglion cells stain positively with synaptophysin, neurofilament protein, and neuron-specific enolase.
Of those, some appear neuronal, featuring small amounts of Nissl substance, somewhat centrally placed nuclei, a prominent nucleolus, apical dendrites pointing to the cortical surface, and positivity for synaptophysin, neurofilament protein, and Neu-N.
We discuss (1) placental alkaline phosphatase, c-Kit, and OCT4 for germinoma, (2) [alpha]-inhibin and D2-40 for capillary hemangioblastoma, (3) phosphohistone-H3 (PHH3), MIB-1/Ki-67, and claudin-1 for meningioma, (4) PHH3, MIB-1/Ki-67, and p53 for astrocytoma, (5) synaptophysin, microtubule-associated protein 2, neurofilament protein, and neuronal nuclei for medulloblastoma, (6) INI1 for atypical teratoid/ rhabdoid tumor, and (7) epithelial membrane antigen for ependymoma.
Other neuronal marker proteins that have been identified in central neurocytoma include neurofilament protein, neuron-associated class III [beta]-tubulin, and microtubule-associated proteins MAP2 and tau.
The excised tumor tissue was fixed in 10% buffered formalin, processed for paraffin sectioning, and stained with hematoxylin-eosin and immunoperoxidase stains for glial fibrillary acidic protein, neurofilament protein, synaptophysin, low-molecular-weight cytokeratin, and desmin.
3] Factors that argue against a neural origin include negative staining for synaptophysin, chromogranin, and neurofilament protein.
Characteristic of the accompanying pathology is the presence of Lewy bodies, which are intracytoplasmic inclusions containing neurofilament proteins and others such as [alpha]-synuclein and parkin.
Neurofilament proteins were present in a few tumor cells.