hodgsonii root reduced the expression levels of neurofilaments
on PC12 cells.
(NFs) in the mature central nervous system are composed of four subunits, light (NF-L), middle (NF-M), and high (NF-H), being about 200 kDa), and [alpha]-internexin.
, this structure moves chemicals and cellular subunits to the far reaches of the nerve cell.
Further examination suggested that the restoration of vision depends on the loss of neurofilaments
that hold the visual system in place.
26) Secondly, increased intracellular calcium may also damage microtubules and neurofilaments
within the axon, thereby disrupting neural connectivity.
Arsenic inhibits neurofilament
transport and induces perikaryal accumulation of phosphorylated neurofilaments
: roles of JNK and GSK-3beta.
Immunohistochemical staining for synaptophysin, neurofilaments
, and S-100 protein demonstrated a normal pattern of immunoreactivity.
Phosphorylation protects neurofilaments
Other such tests encountered during CDC health hazard evaluations include post-chelation urine testing for metal toxicity, use of peripheral neurofilaments
for neurotoxic exposure, measurement of caffeine clearance for hepatotoxic exposure, and use of mold immunoassays for symptoms attributed to mold exposure.
(NFs) are intraneuronal and axonal cytoskeletal framework proteins.
The axonal cytoskeleton, including myelin and the linear orientation of neurofilaments
that keep anisotropy high in healthy white matter, can be perturbed with trauma or disease, including alcoholism, leading to diminished anisotropy, marking disruption of linearity (Arfanakis et al.
The proteins produced in the nucleus are transported via microtubules and neurofilaments
to the synapses that contain mitochondria, which are responsible for energy production, and the synaptic vesicles that store the different neurotransmitters (Figure 3).