neurofilament

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Related to Neurofilaments: Neurofilament proteins

neurofilament

[‚nu̇·rō′fil·ə·mənt]
(physiology)
A type of intermediate filament, composed of three polypeptides (NF-L, NF-M, and NF-H), that helps support and strengthen the axons of nerve cells.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Axons, neurofilaments, and myelin sheaths had normal ultrastructural architecture under TEM.
"An exception, however, is a small piece of so-called neurofilament that is surprisingly resistant to this degradation." The blood test of Jucker and colleagues is based on this protein.
Neurofilament accumulation in giant axons was detected by electron microscope [Figure 1]d-1f].{Figure 1}
The transverse and longitudinal sections of the neurofilaments were observed.
Chitinase-3-like-1 predicted long-term cognitive impairment 1 the PASAT test, and neurofilament light-chain (NfL) predicted long-term disability in the MS severity scale and nine-hole-Peg-test (57).
Meanwhile, the loss of neurofilaments (shown by NF-M immunofluorescence, red) was also detected in neurons of the spinal cord anterior horn, especially at 8 weeks pi, the late stage of clinical progression (g, i).
Wadzinski, "Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments," Brain Research.
Caption: FIGURE 2: Masson's trichome staining (a) and immunostaining for neurofilaments ((b), (d), and (e)) and S100 protein (c) in sections of the cavum conchae, showing nerve profiles inside (c) and out of ((b), (d), and (e)) the auricular cartilage.
Axons were identified by localization of neurofilaments (rabbit polyclonal neurofilament H; 1 : 500; Encor Biotechnology, Gainesville, FL).
A specific sandwich ELISA kit (NS170, Chemicon International, USA-Canada) was used to quantify the heavy chain of phosphorylated neurofilaments (pNF-H) according to the manufacturer's instructions.