References in periodicals archive ?
The neurokinin B/neurokinin 3 receptor system is highly amenable in principle to targeting as a treatment, and I expect that this genetic discovery will lead to intense efforts to understand neurokin B's role in puberty in more detail, and to try to develop clinically valuable drugs.
12) George DT, Gilman J, Hersh J, et al: Neurokinin 1 receptor antagonism as a possible therapy for alcoholism.
Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B.
Though the impact of substance P and neurokinin A on the immune system remains unclear, many studies indicate that, there may also be exerted profound influence on inflammatory responses, by affecting multiple aspects of immune cell function.
The Elisa technique (Phoenix Pharmaceutical, Inc, Germany) was used to identify the substances [beta]-endorphin (ng/ml), substance P (ng/ml) and neurokinin A (ng/ml) in human serum.
Dual and selective antagonism of neurokinin NK(1) and NK(2) receptor-mediated responses in human colon mucosa.
Substance P and other neuropeptides in the neurokinin (NK) family bind to the NK-1 receptor and are involved in pathways for pain, inflammation, and emotional distress.
NK-1 receptors are highly concentrated in the brain and bind neurokinin substance P.
Neurokinin 1 (NK1) Receptor and Substance P Antagonists
Newer agents in different classes are under evaluation including calcium channel blocking agents, potassium channel opening drugs, beta agonists and neurokinin receptor antagonists.
In addition, the neurokinin 1-expressing (NK1R) neurons of the preBotC in the ventrolateral medulla are depleted by 60 per cent in Parkinson's disease and by 89 per cent in individuals with MSA, suggesting substantial damage to the preBotC.