The technology is described in a recent Biomaterials paper by Hesperos CSO James Hickman from the Hybrid Systems Laboratory at the University of Central Florida, "Stem cell derived phenotypic human neuromuscular junction
model for dose response evaluation of therapeutics."
Age-associated alterations of the neuromuscular junction
. Exp Gerontol.
Table 1: The distribution pattern of neuromuscular junctions
according to macroscopic investigation.
Caption: Figure 5: mEJPs recoded at muscle fiber 6 and 7 neuromuscular junctions
from transgenic Drosophila melanogaster larvae.
Pyridostigmine, a reversible acetylcholinesterase inhibitor, improves symptoms by increasing acetylcholine concentration at neuromuscular junction
and stimulating nicotinic receptors .
"The neuromuscular junction
is involved in a lot of very incapacitating, sometimes brutal and fatal disorders, for which a lot has yet to be discovered," says Sebastien Uzel, who led the work as a graduate student in MIT's Department of Mechanical Engineering.
Eaton and lead author Rebekah Mahoney, a graduate student, recorded changes in the neuromuscular junction
synapses of aging fruit flies.
Sprouting of mammalian motor nerve terminals induced by in vivo injection of botulinum type D toxin and the functional recovery of paralysed neuromuscular junctions
. Neurosci Lett 1993; 153:61-64.
The neuromuscular junction
(NMJ) of Drosophila larvae offers an ideal model for studying the role of mitochondrial movements in synaptic plasticity in an intact nervous system because of its organized layout of the motor axons, its transparent muscle fibers, and its conservation of many key synaptic molecules that are also present in mammalian systems (Zhong, 1995; Saitoe and Tully, 2000).
This study showed changes in the infected muscular fiber with alterations in the vessels and neuromuscular junctions
. Parasite group into muscle fiber (FIG.
Botulinum toxins are taken up by nerve cells through pinocytosis and mediate their action by binding to neuromuscular junctions
and preventing acetylcholine release leading to muscular paralysis (16).
Diseases of the Neuromuscular Junctions
Conditions such as myasthenia gravis and congenital myasthenic syndrome (which is detectable at birth) cause problems with eye movement, facial expression, chewing, swallowing, respiration and, occasionally, arm and leg movement.