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Any disease affecting neurons.



a functional weakness of the nervous system accompanied by a decrease in the absolute threshold (also called the stimulus, or sensitivity, threshold); the condition is frequently congenital.

Neuropathy arises as a disturbance in the function of the autonomic nervous system owing to deleterious influences on the fetus as a whole (for example, infection in the pregnant mother, trauma, or poisoning) or on the individual embryonic cells (as occurs when the parents suffer from alcoholism). Family circumstances, upbringing, and illnesses suffered by the infant play a role in the pathogenesis of neuropathy. The symptoms usually emerge in childhood or adolescence. When neuropathy occurs in early childhood, disturbances of sleep and appetite are most characteristic; the infant has difficulty in falling asleep, awakes easily, suckles poorly, and frequently spits up. Later, vomiting occurs, and either diarrhea or constipation develop.

From the preschool years on, increased general excitability and the rapid onset of fatigue and exhaustion are observed, in addition to continued disturbances of sleep and appetite. Children who suffer from neuropathy blush easily in response to irritation. Motor hyperactivity, nervous tics, and stammering are frequent. In adolescence, autonomic-vascular instability becomes more acute, as evidenced by frequently occurring nervous palpitation, abrupt shifts in blood pressure, headaches, dizzy spells, and fainting spells. The prognosis is favorable, with the neuropathic symptoms usually disappearing with age.


Simson, T. Nevropatii, psikhopatii i reaktivnye sostoianiia mladencheskogo vozrasta. Moscow-Leningrad, 1929.
Sukhareva, G. E. Klinicheskie lektsii po psikhiatrii detskogo vozrasta, vol. 2. Moscow, 1959.


References in periodicals archive ?
Neuropathic pain is a common and complex pain condition caused by damage or diseases of the sensory nerves.
The capsaicin 8% patch delivers a high-dose of a synthetic form of capsaicin directly to the damaged pain sensing nerves in the skin that are the source of neuropathic pain.
Develop a practical and standardized tool that quickly diagnoses patients and helps prioritize the discussion of different types of pain, in particular pain that is a mix of both neuropathic and nociceptive pain
Neuropathic pain is not a single disease, but a syndrome caused by a range of different diseases and lesions, which has a considerable impact on the quality of life (QoL).
8) conducted a before-and-after trial of SCI patients with pain, in which they found that gabapentin was effective in decreasing neuropathic pain refractory to conventional analgesics.
PHN, one of the many causes of neuropathic pain, is triggered by a complication of the herpes zoster virus, commonly called shingles.
Neuropathic pain is associated with changes in the transmission of signals between neurons, a process that depends on several types of voltage-gated calcium channels (VGCCs).
A review of the Diabetic Neuropathic Pain products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
The results suggested significant reductions in neuropathic pain in rats assigned to swimming or treadmill running.
4 per cent of the patients in the study with nerve pain were receiving the correct treatment -- leading the authors to call for all doctors managing low- back pain to screen patients for neuropathic pain using the LANSS test to ensure appropriate treatment.
Peripheral neuropathic pain is often described as burning, tingling, electrical, or stabbing by pins and needles.
The diagnosis of neuropathic pain is a clinical one that is "based on a characteristic symptom profile that includes spontaneous sensations such as burning pain, numbness, and tingling, and evoked sensations such as sensitivity to light touch," she said.