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Any disease affecting neurons.



a functional weakness of the nervous system accompanied by a decrease in the absolute threshold (also called the stimulus, or sensitivity, threshold); the condition is frequently congenital.

Neuropathy arises as a disturbance in the function of the autonomic nervous system owing to deleterious influences on the fetus as a whole (for example, infection in the pregnant mother, trauma, or poisoning) or on the individual embryonic cells (as occurs when the parents suffer from alcoholism). Family circumstances, upbringing, and illnesses suffered by the infant play a role in the pathogenesis of neuropathy. The symptoms usually emerge in childhood or adolescence. When neuropathy occurs in early childhood, disturbances of sleep and appetite are most characteristic; the infant has difficulty in falling asleep, awakes easily, suckles poorly, and frequently spits up. Later, vomiting occurs, and either diarrhea or constipation develop.

From the preschool years on, increased general excitability and the rapid onset of fatigue and exhaustion are observed, in addition to continued disturbances of sleep and appetite. Children who suffer from neuropathy blush easily in response to irritation. Motor hyperactivity, nervous tics, and stammering are frequent. In adolescence, autonomic-vascular instability becomes more acute, as evidenced by frequently occurring nervous palpitation, abrupt shifts in blood pressure, headaches, dizzy spells, and fainting spells. The prognosis is favorable, with the neuropathic symptoms usually disappearing with age.


Simson, T. Nevropatii, psikhopatii i reaktivnye sostoianiia mladencheskogo vozrasta. Moscow-Leningrad, 1929.
Sukhareva, G. E. Klinicheskie lektsii po psikhiatrii detskogo vozrasta, vol. 2. Moscow, 1959.


References in periodicals archive ?
These age-related changes may predispose individuals to degenerative disease related to neuropathic pain, and diagnosis is important to establish a proper treatment regimen.
The recognition of neuropathic pain is based on the physical examination of each patient and the careful assessment of their clinical history.
The company said the Proclaim DRG Neurostimulation System will improve the experience of how patients interact with their device, which may lead more patients to consider DRG stimulation for the treatment of chronic neuropathic pain.
Working together with Bristol-Myers Squibb, we have accumulated an extensive amount of data supporting the potential of LX9211 for neuropathic pain and other chronic pain indications, said Praveen Tyle, Ph.
The report provides a snapshot of the global therapeutic landscape of Peripheral Neuropathic Pain
The report reviews pipeline therapeutics for Diabetic Neuropathic Pain by companies and universities/research institutes based on information derived from company and industry-specific sources
Neuropathic pain, on the other hand, is caused by a disease or lesion in the somatosensory nervous system (IASP, 2014).
sup][5] Additionally, we evaluated the antinociceptive effect of najanalgesin in a rat model of neuropathic pain, which was induced by L5 spinal nerve ligation (SNL).
PainDETECT is a simple, self-administered, useful screening questionnaire, which was designed to evaluate neuropathic signs and symptoms without physical examination.
Although findings on the epidemiology of neuropathic pain are not much accurate, investigators have estimated that up to 3% of general population is having this disorder.
Conclusion: Neuropathic pain is prevalent in people with spinal cord injury and adversely affects life quality.
Gabapentinoids, which are now considered to be first-line treatment for post-SCI neuropathic pain, mimic the neurotransmitter GABA and show indirect interaction with the GABA receptor.