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Any disease affecting neurons.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a functional weakness of the nervous system accompanied by a decrease in the absolute threshold (also called the stimulus, or sensitivity, threshold); the condition is frequently congenital.

Neuropathy arises as a disturbance in the function of the autonomic nervous system owing to deleterious influences on the fetus as a whole (for example, infection in the pregnant mother, trauma, or poisoning) or on the individual embryonic cells (as occurs when the parents suffer from alcoholism). Family circumstances, upbringing, and illnesses suffered by the infant play a role in the pathogenesis of neuropathy. The symptoms usually emerge in childhood or adolescence. When neuropathy occurs in early childhood, disturbances of sleep and appetite are most characteristic; the infant has difficulty in falling asleep, awakes easily, suckles poorly, and frequently spits up. Later, vomiting occurs, and either diarrhea or constipation develop.

From the preschool years on, increased general excitability and the rapid onset of fatigue and exhaustion are observed, in addition to continued disturbances of sleep and appetite. Children who suffer from neuropathy blush easily in response to irritation. Motor hyperactivity, nervous tics, and stammering are frequent. In adolescence, autonomic-vascular instability becomes more acute, as evidenced by frequently occurring nervous palpitation, abrupt shifts in blood pressure, headaches, dizzy spells, and fainting spells. The prognosis is favorable, with the neuropathic symptoms usually disappearing with age.


Simson, T. Nevropatii, psikhopatii i reaktivnye sostoianiia mladencheskogo vozrasta. Moscow-Leningrad, 1929.
Sukhareva, G. E. Klinicheskie lektsii po psikhiatrii detskogo vozrasta, vol. 2. Moscow, 1959.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
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Neuropathic pain is usually managed with a variety of pharmacological and non-pharmacological therapies12 Among non-pharmacological treatments Transcranial Electrical Stimulation (TES), acupuncture, massage therapy and Transcutaneous Electrical Nerve Stimulation (TENS) are some of the frequently used modalities/ techniques for relieving neuropathic pain in SCI patients.
In brief, the CFA (oil:saline, 1:1; Sigma) was subcutaneously injected into three unilateral skin sites (30 [micro]L/site; Figure 1) on the face to induce trigeminal neuropathic pain as previously described (17,18).
The PWMT and PWTL in the 12 mg/kg stavudine and 2 mg/kg rapamycin groups were significantly decreased on day 7, 14, 21, 28, 35, and 42 after drug administration compared with those in the control group, and the PWMT and PWTL were the lowest on the 42nd day, indicating that oral administration of stavudine caused peripheral neuropathic pain.
In the present study, the prevalence of neuropathic pain was found to be higher among pregnant women with LPP.
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The consortium will investigate neuron-glia interactions aiming to develop authentic cellular (co-culture) assaid to discover improved treatments of neuropathic pain using neuronal and glial cell types derived from human induced pluripotent stem cells (iPSC), and their co-cultures.