neurotoxicity

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neurotoxicity

[‚nu̇·ro·täk′sis·əd·ē]
(medicine)
Adverse effects on the structure or function of the central and/or peripheral nervous system caused by exposure to a toxic chemical, symptoms include muscle weakness, loss of sensation and motor control, tremors, cognitive alterations, and autonomic nervous system dysfunction.
References in periodicals archive ?
Pathomechanisms of diseases are described with steps at which neuroprotective therapies are directed.
Longitudinal analysis was performed in 11 of the study patients to evaluate the neuroprotective effects of hypermethylation in individuals over their disease course.
To this end they set out to investigate antioxidative and neuroprotective strategies in scopolamine induced murine models of AD.
They also produced evidence suggesting that two other neuroprotective compounds eyed as possible Alzheimer's cures may work through the same mechanism as P7C3.
In animal models, neuroprotective agents, known as glutamate antagonists, minimize brain cell death by inhibiting glutamate release, or blocking glutamate binding at NMDA or AMPA receptor sites.
The idea is that quicker treatment might boost the efficacy of a neuroprotective drug.
Market analysis of currently used products that have a neuroprotective effect are analyzed for the year 2012.
There is a desperate need to develop additional neuroprotective strategies.
Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.
Future hopes In stroke care focus on a combination of a thrombolytic and a neuroprotective agent for better recovery.
I think minocycline has some remarkable neuroprotective effects," says Steven M.