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Related to Neutrophils: Lymphocytes, Monocytes, Basophils, Eosinophils


A large granular leukocyte with a highly variable nucleus, consisting of three to five lobes, and cytoplasmic granules which stain with neutral dyes and eosin.



(also called polymorphonuclear neutrophil leukocyte, microphage), a type of white blood cell, or leukocyte, occurring in vertebrates and man. The diameter of a neutrophil ranges from 9 to 12 μ. The cytoplasm of these cells contains granules that attract both basic and acidic dyes, and this is why these leukocytes are called neutrophils.

A neutrophil is classified according to its degree of maturity: a metamyelocyte is a young neutrophil with an unsegmented nucleus, a rod neutrophil has a nucleus in the shape of a curved rod, and segmented, or filamented, neutrophils have segmented nuclei. Neutrophils are phagocytes that are capable of ingesting small foreign particles, including microbes. By elaborating hydrolytic enzymes, neutrophils can lyse dead tissue. Neutrophilia is an abnormal increase in the concentration of neutrophils in the blood. (SeeLEUKOCYTOSIS.)

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In this study, the researchers suggested that after a hemorrhagic stroke the brain secretes high levels of IL-27, which leads to a second wave of neutrophils arriving with granules filled with higher amounts of healing molecules.
They found that antibiotics disrupted the mice's gut microbiomes, decreasing the activity of neutrophils and blocking these important white blood cells from responding when needed.
The definition of hypersegmentation was set at 4% or more of neutrophils with 5 distinct lobes, connected by filaments or of any number of cells with 6 or more lobes.
One hundred well-stained neutrophils were double-blindly studied in the tail-end of the smears and classified into four groups based on Kosenow's formula: Drumstick as Form A, sessile nodule as Form B, and different types of nuclear projections such as small club, hook, and tags as Form C.
Continuous variables are presented as the mean and standard deviation, and the receiver operating characteristics (ROC) test was used to determine the accuracy of leucocyte, neutrophil, eosinophil, and platelet counts, neutrophil percentage, and MVP for predicting perforation of appendicitis.
Zebrafish has the conserved ortholog of mammalian mpo, myeloperoxidase (mpx), is expressed specially in neutrophils in the developmental stage [16].
Caption: In a study of pregnant monkeys, toxic pigment made by Strep B bacteria destroyed infection-fighting cells called neutrophils (healthy neutrophil, left; one exposed to a pigmented strain of Strep B, middle; one exposed to a hyperpigmented strain, right).
However, under inflammatory conditions, neutrophils become activated and their longevity increases by several fold, which ensures the presence of primed neutrophils at the site of inflammation [19].
Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway.
Surface RANKL of Tol-like receptor4-stimulated human neutrophils activate sosteoclastic bone resorption.