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A large granular leukocyte with a highly variable nucleus, consisting of three to five lobes, and cytoplasmic granules which stain with neutral dyes and eosin.



(also called polymorphonuclear neutrophil leukocyte, microphage), a type of white blood cell, or leukocyte, occurring in vertebrates and man. The diameter of a neutrophil ranges from 9 to 12 μ. The cytoplasm of these cells contains granules that attract both basic and acidic dyes, and this is why these leukocytes are called neutrophils.

A neutrophil is classified according to its degree of maturity: a metamyelocyte is a young neutrophil with an unsegmented nucleus, a rod neutrophil has a nucleus in the shape of a curved rod, and segmented, or filamented, neutrophils have segmented nuclei. Neutrophils are phagocytes that are capable of ingesting small foreign particles, including microbes. By elaborating hydrolytic enzymes, neutrophils can lyse dead tissue. Neutrophilia is an abnormal increase in the concentration of neutrophils in the blood. (SeeLEUKOCYTOSIS.)

References in periodicals archive ?
Certain surface proteins reveal whether neutrophils are resting or have become active; different cell-surface proteins indicate whether neutrophils are young or old.
UW-Madison students have developed the kit-on-a-lid-assay (KOALA) microfluidic technology, which allows them to detect neutrophils using just a single drop of blood.
Neutrophils were separated from 10 mL blood by hypotonic lysis of RBC (Carlson and Kaneko, 1973).
In contrast, the neutrophils of CGD patients are usually able to destroy catalase negative organisms such as pneumococci, streptococci and others because of the [H.
This finding was true for a number of different cancer types, suggesting that neutrophil webs may be a common pathway involved in the spreading of many cancers.
Cytochemical staining of peroxidase was negative, as compared to the control (Figure la, lb), and flow cytometry analysis showed a dramatic decrease in MP0(+) neutrophils (Figure 2).
Rather, when neutrophil counts are low, the patient's immune system enters a fragile equilibrium--described as "bistabilit" in mathematical terms --which can be disrupted easily, with dramatic consequences, by even minute changes in bacterial concentration or neutrophil numbers.
The CPD included volume, conductivity, and 5 different light scatters (median angle light scatter, lower median angle light scatter, upper median angle light scatter, axial light loss measurement, and low-angle light scatter) for neutrophils, lymphocytes, and monocytes.
The alphadefensin family consists of 6 members, 4 of which are found in the primary granules of neutrophils (accounting for 30% of total granule protein), and 2 in the Paneth cells of the crypts of the small intestine.
A few years ago, Caughey's laboratory studied mice infected with the bacterium Mycoplasma pulmonis and found that their neutrophils released histamine.
Neutrophil granulocytes comprise important defenses for the immune system.
Results: Subcutaneous mistletoe therapy has a statistical significant numeric stimulant effect on leukocytes, absolute neutrophils and absolute lymphocytes, which is apparent after 30 days of treatment with injections three times per week.