Nitrofurans


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Related to Nitrofurans: chloramphenicol, nitrofurantoin, Quinolones

Nitrofurans

 

derivatives of furan in which a hydrogen atom is replaced by a nitro group. Nitrofurans have a broad spectrum of antimicrobial action, which is based on their capacity to inhibit respiration of the microbial cell. In surgery, nitrofurans are used for treatment of wounds and for prophylaxis of postoperative complications (Nitrofurazone); in obstetrics, gynecology, and urology they are used for treatment of infectious diseases (Furadonine and Furazolidone). They are also used for treatment of giardiasis and trichomoniasis (Furazolidone).

References in periodicals archive ?
Honey Nitrofuran Honey (1 g) was extracted using 10 metabolites and mL MeCN with MgSO4 and NaCl, without nitroimidazole d-SPE.
Furazolidone is a nitrofuran antibiotic often applied illegally as animal or fish feeds, although it is prohibited by many countries due to its carcinogenicity and other adverse health effects [12].
Nitrofuran antibiotics were ed from use in the uropean Union (EU) in 1995 because of concerns that their residues were carcinogenic.
Approved (upper) limits applicable in the aforementioned testing are 0.002 ppm for fenitrothion and 0.01 ppm for oxolinic acid, acetochlor, and triazophos; nitrofurans and chloramphenicol must not be detected in food.
An EC statement said: "The Commission proposal provides that all consignments of crustaceans originated from India and intended for food or feed to be tested at the place of origin for presence of nitrofurans or their metabolites.
Resistance to nitrofurantoin was lower than expected, given the documented illicit use of nitrofurans in Portugal by poultry producers in 2002-2003 (DGV, 2004).
These small and medium-sized businesses have been facing health control problems regarding importing countries, with shipments being seized or blocked over contamination concerns--such as nitrofurans. "There is a need to adopt HACCP", he said.
Classically, after ingestion of certain agents like sulfamides, antipyretics, nitrofurans and antimalarial medicines, like the primaquine and chloroquine, the patient develops fever, black color urine, ictericia and anemia.
Dermatologists most often prescribed tetracyclines (75%); emergency medicine physicians, macrolides (42%); ob.gyns, nitrofurans (27%); pediatricians, penicillins (38%); and surgeons, fluoroquinolones (25%).
prescribe nitrofurans more frequently than any other specialty.
Developed empirically over three decades ago, the currently available drugs nitrofurans and nitroimidazoles, are unsatisfactory due to frequent toxic side-effects and limited efficacy, particularly in the prevalent chronic form of the disease.
Some Anti-thyroid and Related Substances, Nitrofurans and Industrial Chemicals; IARC Monogr Evai Carcinog Risk Chem Man 7.