Transition metals bind nucleic acid more tightly than [Mg.sup.2+] or [K.sup.+], which is largely due to the interaction with nucleophilic nitrogenous bases
(N7 purine) .
From the results reported here, the accelerating effect of 2HT and IMZ salts can be justified, taking into consideration: (1) the presence of nitrogenous bases
in both types of salts, in the imidazolinium ring and after thermal degradation occurring in vulcanization in 2HT, and (2) the increased mobility of sulfur anionic species.
Instead of using the four nitrogenous bases
of DNA, in this study the researchers used three monomers .
15: Classical bioisosterism among nitrogenous bases
* the features that describe the nitrogenous bases
as categorical effects (complimentary pairs as the base pairs, similar pairs as pyrimidines and purines, chiral pairs as the right and left twist of the helix, polar pairs as the bonding arrangements), and
Team member Yuichi Ando said among the four nitrogenous bases
-- thymine (T), adenine (A), guanine and cytosine -- the researchers examined patient sequences of consecutive T and A bases called ''TATA boxes,'' which exist in genes activating enzymes that can prevent side effects of the drug.
Each rung became known as a base pair, because it consisted of a pair of nitrogenous bases
(nucleotides) attached end to end.
DNA is made up of four types of nitrogenous bases
: adenine ("A"), thymine ("T"), guanine ("G") and cytosine ("C").