nociceptor

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Related to Nociceptive neuron: Nocireceptors

nociceptor

[′nō·sə‚sep·tər]
(physiology)
A sensory nerve ending that is particularly sensitive to noxious stimuli such as chemical changes in surrounding tissue evoked by injury.
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Release of neurotransmitters from nociceptive neurons (and at all CNS synapses) depends on N-type and P/Q-type voltage-sensitive calcium channels (VSCCs).
The test consists of two different phases that can be separated in time: the first one is generated in the periphery through the activation of nociceptive neurons by the direct action of formalin and the second phase occurs through the activation of the ventral horn neurons at the spinal chord level (Tjolsen et al.
CCL21 potently activates resident microglia within the ventral posterolateral (VPL) nucleus of the thalamus as well as the lumbar dorsal horn, and in turn, microglia pathologically modulate the firing properties of nociceptive neurons at these locations.
Microglia may also play different roles in a variety of structures as well, which in the case of thalamic nociceptive neurons may include further amplification of signals received from spinal structures [13].
However, it was known that constriction induced by acetic acid was considered to be a non-selective anti-nociceptive model, since acetic acid indirectly induced the release of endogenous mediators stimulated the nociceptive neurons that were sensitive to non-steroidal antiinflammatory drugs (NSAIDs) (Sanchez-Mateo et al.
Acetic acid acts indirectly by inducing the release of endogenous mediators, which stimulate the nociceptive neurons sensitive to NSAIDs (non-steroidal anti-inflammatory drugs) and/or opioids (Collier et al.