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Primarily found in the nociceptive neurons of the peripheral nervous system, stimulation of the transient receptor potential vanilloid receptor type 1 (TRPV1) results in a cation influx and the production of an action potential that consequently results in the sensation of pain.
Using both noxious thermal stimuli and optogenetic stimulation of nociceptive neurons, we assay the development of the nocifensive response of Drosophila larvae over time.
Modulation of paratrigeminal nociceptive neurons following temporomandibular joint inflammation in rats.
Neurons with a wide variety of calcium channels in their cellular membrane have been described in nociceptive pathways and centers (31), playing an important role for sensitization and potentiation of nociceptive neurons and their neuronal network (8, 9).
Such a reduction in excitability would reduce or eliminate spontaneously evoked action potentials that propagate along the axons of the nociceptive neurons and give rise to pain.
Avery and other researchers were able to show that whether the worms ate alone or in groups was dictated by the existence of the ADL and ASH nociceptive neurons.
Voltage-gated sodium channels in peripheral nociceptive neurons as targets for the treatment of pain (Theodore R.
The excitatory amino acid glutamate is the major excitatory neurotransmitter released at the central terminals of primary afferent nociceptive neurons after noxious stimulation (Bridges et al.
CCL21 potently activates resident microglia within the ventral posterolateral (VPL) nucleus of the thalamus as well as the lumbar dorsal horn, and in turn, microglia pathologically modulate the firing properties of nociceptive neurons at these locations.
Thus, NGF appears critical for maintaining the neurochemical homeostasis in nociceptive neurons, and its administration may be beneficial in restoring and/or maintaining opioid analgesia in chronic pain conditions resulting from traumatic nerve injury.