nociceptor

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Related to Nociceptors: Pacinian corpuscle, Gate control theory

nociceptor

[′nō·sə‚sep·tər]
(physiology)
A sensory nerve ending that is particularly sensitive to noxious stimuli such as chemical changes in surrounding tissue evoked by injury.
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The PRDM12 protein helps orchestrate nociceptor development early in gestation, studies on human cells and frog and mouse embryos suggest.
In the study, they induced asthma in mice by exposing them to dust mites or another allergen, ovalbumin, then administered QX-314 via nebulizer to silence the nociceptors.
The intraoperative injury barrage caused by nerve damage sensitises nociceptors in the surgical field, creating ectopic activity in sprouts of injured primary afferents and in somata of intact neurones in neighbouring dorsal root ganglia (10).
Following injury, the neurochemicals that are released trigger peripheral changes that increase the excitability of high-threshold nociceptors (a manifestation of neuroplasticity), resulting in peripheral sensitization, which is characterized by increased sensitivity to pain at the site of injury {primary hyperalgesia).
Once the cortical spreading depression occurs, hydrogen and potassium ions diffuse to the pia mater and activate C-fiber meningeal nociceptors, which release a proinflammatory mix of neurochemicals such as calcitonin gene-related peptide that leads to plasma extravasation, which leads to neurogenic inflammation of the trigeminovascular complex (Soma & Ko, 2008).
Nociceptors are distributed throughout the body, including the skin, muscles, joints, and organs.
Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy.
The papers are organized into sections covering basic mechanisms of muscle pain including morphology and functional types of peripheral muscle nociceptors, central neurophysiological mechanisms involved in nociception, and cortical representation of muscle nociception; factors influencing muscle nociceptive mechanisms, such as genetics, gender, chronic pain, analgesics, and pain from other tissues; the effects of musculoskeletal pain on muscle function in the lower back, neck, and jaw muscle systems; and advanced neurophysiological assessments of muscle function.
Tissue damage will stimulate nociceptors and generate an action potential, which is transmitted by thin myelinated Aa fibres and unmyelinated C fibres (both are called primary afferents) to the dorsal horn in the spinal cord.
Tackling pain at the source: new ideas about nociceptors.
11) Our current understanding is that patients who have heartburn symptoms but no erosions (NERD) have microscopic defects in mucosal barrier function that allow acid pepsin to reach nociceptors and cause pain, but not sufficient to progress to erosions.
Nociceptive pain involves stimulation of intact nociceptors.