noncompetitive inhibition

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noncompetitive inhibition

[¦nän·kəm′ped·əd·iv ‚in·ə′bish·ən]
(biochemistry)
Enzyme inhibition in which the inhibitor can combine with either the free enzyme or the enzyme-substrate complex so that the inhibitor does not compete with the substrate for the enzyme.
References in periodicals archive ?
This effect was found to be a non-competitive inhibition.
Donepezil is a piperidine-type cholinesterase inhibitor, which exerts reversible, non-competitive inhibition of acetylcholinesterase, being structurally distinct from the other cholinesterase inhibitors available today.