noncompetitive inhibition

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noncompetitive inhibition

[¦nän·kəm′ped·əd·iv ‚in·ə′bish·ən]
(biochemistry)
Enzyme inhibition in which the inhibitor can combine with either the free enzyme or the enzyme-substrate complex so that the inhibitor does not compete with the substrate for the enzyme.
References in periodicals archive ?
64 mg/kg and showed the characteristic of a noncompetitive inhibitor.
Ketamine is thought to act as a noncompetitive inhibitor of the N-methyl-D-aspartate (NMDA) receptor, which is part of the glutaminergic neurotransmitter system.
One of the metabolites, urolithin A, was the most potent uncompetitive inhibitor of CYP1B1 exhibiting two fold selectivity over CYP1A1, while another, urolithin B, was a noncompetitive inhibitor with three fold selectivity.
Quenching-recovery experiments were also performed using "quenched" equimolar calcein-nickel(II) solutions and added catalase, in order to quantify binding between this important enzyme and the noncompetitive inhibitor, Ni(II).
One explanation may be that 2, as a noncompetitive inhibitor, binds at an allosteric site.