noncompetitive inhibition

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noncompetitive inhibition

[¦nän·kəm′ped·əd·iv ‚in·ə′bish·ən]
(biochemistry)
Enzyme inhibition in which the inhibitor can combine with either the free enzyme or the enzyme-substrate complex so that the inhibitor does not compete with the substrate for the enzyme.
References in periodicals archive ?
64 mg/kg and showed the characteristic of a noncompetitive inhibitor.
In vivo effect of Schisandrin B on cytochrome P450 enzyme activity
Ketamine is thought to act as a noncompetitive inhibitor of the N-methyl-D-aspartate (NMDA) receptor, which is part of the glutaminergic neurotransmitter system.
Ketamine lifted bipolar depression in 40 minutes
One of the metabolites, urolithin A, was the most potent uncompetitive inhibitor of CYP1B1 exhibiting two fold selectivity over CYP1A1, while another, urolithin B, was a noncompetitive inhibitor with three fold selectivity.
Cancer protection by pomegranate
Quenching-recovery experiments were also performed using "quenched" equimolar calcein-nickel(II) solutions and added catalase, in order to quantify binding between this important enzyme and the noncompetitive inhibitor, Ni(II).
Fluorescence detection of Ni(II) and investigation of Ni(II)-catalase binding
92 [mu]M), a noncompetitive inhibitor of CYP3A4 [K.
Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro
One explanation may be that 2, as a noncompetitive inhibitor, binds at an allosteric site.
Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens
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