51[micro]M, and the possible mechanism of inhibition is shown the characteristic of noncompetitive inhibitors
MSI-1436 is the only reversible, noncompetitive inhibitor
of PTP1B in clinical stage development that functionally inhibits PTP1B in the periphery and in the hypothalamus.
Dihydrotanshinone was not only a potent competitive inhibitor of human CYP1A2 and CYP2C9, but also a potent noncompetitive inhibitor
of human CYP3A4.
The inhibition kinetics analyses unveil that compounds 1 and 2 are noncompetitive inhibitors.
Hence both 1 and 2 are noncompetitive inhibitors of mushroom tyrosinase.
The in vitro kinetics demonstrates that MSI-1436 is an allosteric, noncompetitive inhibitor
TXA and EACA are lysine analogs that function as competitive inhibitors of plasminogen activation and, at much higher concentrations, noncompetitive inhibitors
As noncompetitive inhibitors
of the enzyme reverse transcriptase, their antiviral activity is additive or synergistic with other antiretroviral agents.
This alkaloid inhibited AChE in the same fashion as some AD drugs including donepezil, tacrine and rivastigmine which are noncompetitive inhibitors
(Zhao and Tang 2002).