51[micro]M, and the possible mechanism of inhibition is shown the characteristic of
noncompetitive inhibitors.
MSI-1436 is the only reversible,
noncompetitive inhibitor of PTP1B in clinical stage development that functionally inhibits PTP1B in the periphery and in the hypothalamus.
Dihydrotanshinone was not only a potent competitive inhibitor of human CYP1A2 and CYP2C9, but also a potent
noncompetitive inhibitor of human CYP3A4.
The inhibition kinetics analyses unveil that compounds 1 and 2 are noncompetitive inhibitors.
Hence both 1 and 2 are noncompetitive inhibitors of mushroom tyrosinase.
The in vitro kinetics demonstrates that MSI-1436 is an allosteric,
noncompetitive inhibitor of PTP-1B.
TXA and EACA are lysine analogs that function as competitive inhibitors of plasminogen activation and, at much higher concentrations,
noncompetitive inhibitors of plasmin.
As
noncompetitive inhibitors of the enzyme reverse transcriptase, their antiviral activity is additive or synergistic with other antiretroviral agents.
This alkaloid inhibited AChE in the same fashion as some AD drugs including donepezil, tacrine and rivastigmine which are
noncompetitive inhibitors (Zhao and Tang 2002).
