diazepam

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Related to Nordiazepam: oxazepam, lorazepam, temazepam

diazepam

[dī′az·ə‚pam]
(pharmacology)
C16H13ClN2O A benzodiazepine with a melting point of 125-126°C; used as a minor tranquilizer to relieve muscle spasms, anxiety, and tension. Also known by trade name Valium.
References in periodicals archive ?
The diazepam, nordiazepam, and oxazepam pharmacokinetic profiles obtained with the probes, which measured concentrations in whole blood, compared with the results of conventional analyses from plasma are shown in Fig.
The same was true for nordiazepam and oxazepam, which showed single- and double-exponential elimination, respectively (Table 1).
On the other hand, the free concentration of nordiazepam remained almost constant for the first hour, followed by a single-exponential decrease.
The following controls were run routinely in each assay: cutoff calibrator (morphine, 10 [micro]L; D-methamphetamine, 100 [micro]g/L; nordiazepam, 100 [micro]g/L; BE, 150 [micro]g/L; PCP, 10 [micro]g/L; THCA, 30 [micro]g/L); negative control (drug-free blood or urine); positive blood control (morphine, 100 [micro]g/L; D-methamphetamine, 300 [micro]g/L; nordiazepam, 300 [micro]g/L; BE, 300 [micro]g/L; PCP, 15 [micro]g/L; THCA, 50 [micro]g/L); and positive urine control (morphine-3-glucuronide, 300 [micro]g/L; D-methamphetamine, 300 [micro]g/L; nordiazepam, 500 [micro]g/L; BE, 300 [micro]g/L; PCP, 15 [micro]g/L; THCA, 50 [micro]g/L).
Dose-response curves for morphine-3-glucuronide, methamphetamine, nordiazepam, BE, PCP, and THCA in urine are shown in Fig.
Slopes for methamphetamine, nordiazepam, and BE assays were comparable.
Benzodiazepine analytes for which detection was improved include lorazepam, nordiazepam, oxazepam, and temazepam.
CEDIA CEDIA GC/MS result, [micro]g/L 25 -39 10 Nordiazepam <25; oxazepam 51; temazepam <25 28 -51 3 Nordiazepam <25; oxazepam 35; temazepam <25 236 -81 53 Lorazepam 334; [alpha]- hydroxyalprazolam <25; [alpha]-hydroxytriazolam <25 628 -10 24 Nordiazepam <25 674 -80 19 Lorazepam 334 685 -20 7 Lorazepam 48; 7-aminoclonazepam 202 786 -7 16 [alpha]-Hydroxyalprazolam 84 799 -85 49 Nordiazepam <25; lorazepam 199 831 -52 217 Lorazepam >500 850 -47 192 Nordiazepam <25; oxazepam 134; temazepam >500 882 -2 8 Nordiazepam <25; oxazepam 27; hydroxyethylflurazepam <25 910 -53 4 Nordiazepam <25; oxazepam 42; temazepam 26 984 -34 32 Nordiazepam <25; oxazepam 103 (a) rate [greater than or equal to] mA/min is considered positive.

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