Norleucine


Also found in: Medical.

Norleucine

 

(also α-aminocaproic acid), an amino acid whose structural formula is CH3(CH2)3CH(NH2))COOH. Nor-leucine does not occur in nature and exhibits no physiological activity. Like norvaline, it is primarily used as a model in developing methods of amino-acid synthesis.

Mentioned in ?
References in periodicals archive ?
We followed the previously reported dabsyl chloride derivatization procedure for standard amino acid mixture and CSF samples and gradient HPLC analysis (18), with the exception that 1 nmol norleucine was added as an internal calibrator before dabsylation to confirm complete derivatization.
Results were calculated with norleucine as internal calibrator.
Pleasanton, CA, USA) using ninhydrin for postcolum derivatization and norleucine as the internal standard.
Amino acid composition was determined with Technicon Amino Acid Analyzer (TSM-1 Technicon Instrument Basingstoke, UK) using Norleucine as internal standard.
Amino acid derivatives were identified by their relative retention times based on the reference peaks for retention time (methionine sulfone and norleucine, both of which were added to the internal standard solution).
Samples were hydrolyzed for 24 hours at 110[degrees]C with 6 mol/HCL containing 2 g/L reagent grade phenol and 5,000 nmol norleucine (internal standard) in evacuated and sealed ignition tubes.
5 g sample was weighed into a 100 ml flat bottomed flask, 1 ml of Norleucine standard solution, 5 ml of performic acid in ice bath.