Jagged and Delta interact with the Notch receptor on the cell surface to initiate the conformational change in the Notch extracellular domain .
Amongst them, Notch receptors are the most widely studied for their contribution to development and progression of cancers, and resistance to existing therapies .
Moreover, Wang says, the role his team has described for the Notch receptor in angiogenesis makes the molecule a potential target of drugs for head-and-neck cancers and perhaps for other solid tumors.
In a series of laboratory experiments, the investigators observed that Jagged1 on a tumor cell binds to molecules called Notch receptors on adjacent blood vessel-lining, or endothelial, cells.
They also observed upregulation of the Notch pathway in breast cancer stem cells via upregulation of Notch receptor
patent on a method of identifying cancer tissue likely to be sensitive or resistant to treatment with an inhibitor of Notch receptor
The extracellular domain (NECD) of the Notch receptor
is pulled away from the intracellular domain (NICD) exposing a site at which two proteolytic cleavage events occur.
are evolutionarily conserved cell surface receptors important for cell fate decisions and embryonic development (Osborne and Minter 2007).
Recently, many researchers have demonstrated that the Notch signaling pathway, encompassing Notch receptors
and ligands, is a very important way to modulate T lymphocyte development (Jaleco et al.
Evidence for differential expression of Notch receptors
and their ligands in melanocytic nevi and cutaneous malignant melanoma.
Monoclonal antibodies to Notch receptors
may enable targeting of tumor autonomous and tumor micro-environmental processes
Previously published studies have shown that Dll4 and its receptor family, known as the Notch receptors
, play a role in vascular development, and further, that Dll4 is required for normal vascular development and is strongly expressed in tumor vessels.