To their surprise, the researchers found that the ketones stimulate the Notch signaling
pathway, which is known to be critical for regulating stem cell functions such as regenerating damaged tissue.
also plays a role in specifying the sensory domains within the otic placode by inducing the proliferation of undifferentiated presensory cells, upregulating Sox2 activity, and inhibiting Ngn1 activity (19).
is one of the pathways, very often deregulated in NSCLC.
pathway plays an important role in tumorigenesis in several solid and hematological malignancies.
The team was then able to observe--in isolated cells, in muscle tissue, and in living animals--that the Hesl protein, which is part of the Notch signaling
pathway, is produced in an oscillatory manner.
It is well known that Notch signaling
is frequently deregulated in human malignancies including pancreatic cancer.
The present study, therefore, sought to examine the effects of 9-cis-RA and 1,25[(OH).sub.2][D.sub.3] on the inhibition of the Wnt and Notch signaling
pathways in oligodendrogenesis.
And although both teams were able to show that NOTCH2NL is involved in the well-studied Notch signaling
pathway, Vanderhaeghen acknowledges that there is still uncertainty around the exact mechanism by which NOTCH2NL tips the balance between differentiation and regeneration.
Inherited or acquired defects in the Notch signaling
pathway may also play a role, because Notch is an important protein for normal follicle development and regulation of the immune response (15).
Age, early menarche, late menopause, obesity in postmenopausal women, high concentration of endogenous estrogen, and heredity are the main predisposing factors for developing breast cancer, while recently there has been growing interest in the Notch signaling
pathway and its role in breast cancer.