Notch signaling


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Notch signaling

[′näch ‚sig·nəl·iŋ]
(embryology)
An evolutionarily conserved developmental pathway utilized during the differentiation of a plethora of tissue types, in organisms as diverse as nematodes and humans.
References in periodicals archive ?
Recent evidence suggests that Notch signaling is important in a mouse model of allergic asthma.
NEW YORK, July 20, 2015 /PRNewswire/ -- Aberrant Notch signaling has been linked to a number of malignancies including leukemias, lymphomas and carcinomas of the breast, skin, lung, cervix and kidneys.
The team's previous research revealed that inhibition of the Notch signaling pathway increases hair cell differentiation and can help restore hearing to mice with noise-induced deafness.
Later chapters introduce more recent therapies that target Notch signaling, the role of cancer stem cells in triggering angiogenesis, and the potential use of genetically modified macrophages as anti-cancer agents.
Recently, many researchers have demonstrated that the Notch signaling pathway, encompassing Notch receptors and ligands, is a very important way to modulate T lymphocyte development (Jaleco et al.
Notch signaling in hematopoiesis and early lymphocyte development.
In section III which deals with targeting of cancer stem cell pathways, there are three chapters that cover Hedgehog/GLI signaling in cancer (Chapter 7), targeting of the notch signaling pathway in cancer stem cells (Chapter 8) and TGF-[beta] Notch and Wnt in normal and malignant stem cells: differentiating agents and epigenetic modulation (Chapter 9).
All gamma secretase inhibitors interfere with Notch signaling.
Rational targeting of Notch signaling in breast cancer.
On the other hand, it is generally believed that Notch signaling is essential for tumor angiogenesis.
Several other cancers, including melanoma and lung, ovarian, and pancreatic cancer, also have activated Notch signaling.
Exposure to the young blood reactivated a system of proteins inside the cells called the Notch signaling pathway, which is crucial for triggering the cells' muscle-repair functions.