Recent evidence suggests that Notch signaling
is important in a mouse model of allergic asthma.
NEW YORK, July 20, 2015 /PRNewswire/ -- Aberrant Notch signaling
has been linked to a number of malignancies including leukemias, lymphomas and carcinomas of the breast, skin, lung, cervix and kidneys.
The team's previous research revealed that inhibition of the Notch signaling
pathway increases hair cell differentiation and can help restore hearing to mice with noise-induced deafness.
Later chapters introduce more recent therapies that target Notch signaling
, the role of cancer stem cells in triggering angiogenesis, and the potential use of genetically modified macrophages as anti-cancer agents.
Recently, many researchers have demonstrated that the Notch signaling
pathway, encompassing Notch receptors and ligands, is a very important way to modulate T lymphocyte development (Jaleco et al.
in hematopoiesis and early lymphocyte development.
In section III which deals with targeting of cancer stem cell pathways, there are three chapters that cover Hedgehog/GLI signaling in cancer (Chapter 7), targeting of the notch signaling
pathway in cancer stem cells (Chapter 8) and TGF-[beta] Notch and Wnt in normal and malignant stem cells: differentiating agents and epigenetic modulation (Chapter 9).
All gamma secretase inhibitors interfere with Notch signaling
Rational targeting of Notch signaling
in breast cancer.
On the other hand, it is generally believed that Notch signaling
is essential for tumor angiogenesis.
Several other cancers, including melanoma and lung, ovarian, and pancreatic cancer, also have activated Notch signaling
Exposure to the young blood reactivated a system of proteins inside the cells called the Notch signaling
pathway, which is crucial for triggering the cells' muscle-repair functions.