Notch signaling

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Notch signaling

[′näch ‚sig·nəl·iŋ]
(embryology)
An evolutionarily conserved developmental pathway utilized during the differentiation of a plethora of tissue types, in organisms as diverse as nematodes and humans.
References in periodicals archive ?
The above results showed that normal fetuses have a greater proportion of T cell subsets at earlier gestation periods, and the genes expression of Notch signaling pathway has the corresponding change with T cells development.
Chapter 8 on targeting of Notch signaling pathway in cancer stem cells describe how pharmacological strategies based on targeting components of the Notch signaling pathway that include blockage of receptor/ ligand interaction and inhibition of the release of NICD (Notch intracellular domain) can be used as therapeutic approaches to selectively target cancer stem cells.
Demcizumab (OMP-21M18) is a humanized monoclonal antibody that inhibits DLL4 in the Notch signaling pathway.
In their study, they found that when BCL6 inhibits the Notch signaling pathway during the early stages of embryo development, the alignment of the embryo's internal organs is affected, which can lead to a congenital disorder.
However, the Notch signaling pathway, which creates the equivalent of a molecular highway across a cell's membrane, is involved in many types of cell-to-cell interaction, including neuron development, stem cell differentiation and apoptosis (programmed cell death).
Most of the gamma secretase inhibitors in development are Notch-sparing molecules, thereby avoiding typical side effects of the Notch signaling pathway, e-g.
The Notch signaling pathway has been found to play central roles in humans in stem cell maintenance, cell fate decisions, and in cancer as well.