Notch signaling

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Notch signaling

[′näch ‚sig·nəl·iŋ]
(embryology)
An evolutionarily conserved developmental pathway utilized during the differentiation of a plethora of tissue types, in organisms as diverse as nematodes and humans.
References in periodicals archive ?
The expression of genes, which fonn the basis of the Notch signaling pathway, is regulated in part by microRNAs (miRNAs), which are short molecules that can inhibit or activate genes.
3,5,7) Several signaling pathways have been associated to the development of the craniofacial complex, some of the most studied are BMP (Bone Morphogenetic Protein), SHH (Sonic Hedgehog), WNT (Wingless), TGF-beta (Transforming Growth Factor Beta), FGF (Fibroblast Growth Factor), and the NOTCH signaling pathway has been recently associated to it.
The above results showed that normal fetuses have a greater proportion of T cell subsets at earlier gestation periods, and the genes expression of Notch signaling pathway has the corresponding change with T cells development.
Chapter 8 on targeting of Notch signaling pathway in cancer stem cells describe how pharmacological strategies based on targeting components of the Notch signaling pathway that include blockage of receptor/ ligand interaction and inhibition of the release of NICD (Notch intracellular domain) can be used as therapeutic approaches to selectively target cancer stem cells.
Demcizumab (OMP-21M18) is a humanized monoclonal antibody that inhibits DLL4 in the Notch signaling pathway.
Our investigation suggested that Notch could be up-regulated in thyroid cancer to over-activate Notch signaling pathway which may inhibit ATC cell proliferation, induce G1 arrest, inhibit cell invasion, and promote apoptosis.
Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway," Cancer Research, vol.
In addition, the Notch signaling pathway has a second function in muscle development.
In their study, they found that when BCL6 inhibits the Notch signaling pathway during the early stages of embryo development, the alignment of the embryo's internal organs is affected, which can lead to a congenital disorder.
Our work has identified the Notch signaling pathway as a central regulatory 'switch' that controls the differentiation of airway basal stem cells," said Jason Rock, Ph.
Most of the gamma secretase inhibitors in development are Notch-sparing molecules, thereby avoiding typical side effects of the Notch signaling pathway, e-g.