The milestone payment is linked to Sanofi's dosing of the first human volunteers in a Phase I clinical trial of SAR441169, a novel inverse agonist of the nuclear hormone receptor
The milestone payment is in connection with Sanofi's dosing of the first human volunteers under its Phase I Psoriasis clinical trial of SAR441169, a novel inverse agonist of the nuclear hormone receptor
ROR?t, a key regulator of the cytokine immune pathway, which leads to the differentiation of T cells to a pro-inflammatory subtype of T helper cells called Th17.
Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor
pathway," Journal of Biological Chemistry, vol.
Bronnegard, "Cardiac nuclear hormone receptor
mrNA in heart failure
However, their possible target(s) within the nuclear hormone receptor
superfamily has remained unknown.
The vitamin D receptor (VDR) is a nuclear hormone receptor
that controls transcription of target genes.
LXR is a nuclear hormone receptor
that is an important regulator of cholesterol metabolism in mammals.
We have designed primers for polymerase chain reaction (PCR) to examine the possible involvement of ultraspiracle, (Usp), an insect nuclear hormone receptor
and a putative receptor for JH in the process of histolysis.
They bind the peroxisome proliferator--activated receptor gamma, a nuclear hormone receptor
that influences the expression of several human genes, including a fatty acid transporter, a fatty acid--binding protein, lipoprotein lipase, and a glucose transporter.
The product is an investigational, selective and non-steroidal agonist of the (FXR), which is a nuclear hormone receptor
that is highly expressed in the gastrointestinal tract and liver.
Nr0B1 (DAX1) is located on the short arm of the X chromosome (Xp21.3-p21.2) and encodes for an orphan nuclear hormone receptor
that functions as a transcriptional regulator of other genes .
The human genome contains 48 nuclear hormone receptor
genes, comprising a large family of ligand-dependent transcription factors.