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Related to Nuclear pleomorphism: hyperchromatism


The occurrence of more than one distinct form of an organism in a single life cycle.



an environmentally produced change in the incidence of disease and causes of death as well as in the properties of individual diseases, that is, nosologic entities (see NOSOLOGY).

During the 20th century, extensive immunization of populations and nationwide preventive measures in economically developed countries have eradicated many infectious diseases, for example, plague and poliomyelitis, and have sharply reduced infant mortality caused by infectious diseases. Changes in living conditions have reduced the incidence of diseases that stem from nutritional deficiency, for example, avitaminoses and iron-deficiency anemia. On the other hand, the incidence of injuries, tumors, and cardiovascular and viral diseases has increased.

New hereditary and occupational diseases have resulted from such environmental changes as those that accompany the growth of the chemical industry. Therapy-induced pleomorphism is a change in the clinical picture of a disease as a result of treatment. For example, the use of drugs has led to the disappearance of severe forms of thyrotoxicosis and anemia. Similarly, tuberculous meningitis, comas in diabetes mellitus, and acute pulmonary suppuration have become rare. In leukemia, tumor cells have disappeared from bone marrow because of the use of cytostatic agents, but they multiply in the nervous system and viscera. Undesirable side effects may follow medicinal treatment, and beyond a certain intensity these constitute a drug disease. The aftereffects of gastric or cardiac surgery, for example, can also give rise to disease.

Diseases that have received a new nosologic classification because of the growth of medical knowledge should not be considered examples of pleomorphism.


Davydovskii, I. V. Patologicheskaia anatomiia i patogenez boleznei cheloveka, 3rd ed., vols. 1–2. Moscow, 1956–58.
Shul’tsev, G. P. “Terapevticheskii patomorfizm.” Klinicheskaia meditsina. 1973, no. 6.
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This study also confirmed that if the biopsy does not have nuclear pleomorphism, loss of polarity, or cribriforming glands, it should not be diagnosed as HGD or carcinoma.
Caption: Figure 1: Histopathology sections showing spindle-shaped tumour cells arranged in long intersecting fascicles, with moderate nuclear pleomorphism and increased mitosis.
Caption: Figure 6: Higher magnification photomicrograph featuring sarcomatoid component with spindle proliferation, nuclear pleomorphism, and increased mitotic activity.
The International Society of Urological Pathology grading system for clear cell and papillary renal cell carcinoma (3) Grade Description 1 Nucleoli absent or inconspicuous and basophilic at x400 magnifcation 2 Nucleoli conspicuous and eosinophilic at x400 magnifcation, and visible but not prominent at x100 magnifcation 3 Nucleoli conspicuous and eosinophilic at x100 magnifcation 4 Extreme nuclear pleomorphism and/or multinucleated tumor giant cells and/or rhabdoid and/or sarcomatoid differentiation
Neoplasm constituted of glial cells with nuclear pleomorphism and eosinophilic cytoplasm arranged in sheets; B.
The cellular morphology includes nuclear pleomorphism with mitotic figures.
The tumor cells had marked nuclear pleomorphism, high nuclear: cytoplasmic (N : C) ratio, and prominent nucleoli (Figure 2(c)).
HandE stained microscopic glass slides were reviewed by two pathologists and were analyzed for various histological features including growth pattern, architecture, neurofibrillary matrix, rosettes, nuclear pleomorphism, nucleoli, mitotic activity, necrosis and calcification.
The malignant transformation in the CEOT is indicated by high mitotic activity, increased nuclear pleomorphism, increased proliferative activity measured with the MIB-1 index, and vascular invasion.
Both the epithelial component and the spindle cell component showed nuclear pleomorphism and a brisk mitotic activity (Figure 3).
Sections from a core biopsy showed a spindle cell neoplasm composed of bundles of bland-looking spindle cells with eosinophilic cytoplasm without mitoses, necrosis, or nuclear pleomorphism (Figure 3).
The proliferation of tumour showed moderate nuclear pleomorphism, high mitotic activity, with necrosis and vascular invasion; the endocervix presented an area of H-SIL (high grade squamous intraepithelial lesions) and chronic endocervicitis; myometrium with multiple leiomyoma nodules.