The findings indicated that the drug zeroes in on mutated nuclear receptors
found in cancer, leaves normal proteins alone.
According to the company, the NR2F6 nuclear receptor
has been identified as a potentially important immune cell inhibitor (an immune checkpoint) and cancer stem cell differentiator.
Published in the August issue of The Journal of Clinical Investigation (JCI), the study showed that when the researchers blocked the effects of the nuclear receptor
PPARgamma in a small number of brain cells in mice, the animals ate less and became resistant to a high-fat diet.
Cell-based INDIGO Nuclear Receptor
Assay Kits are available for purchase in North America directly and worldwide through partnerships with leading distributors.
The story for nuclear receptors
is similar, with the most commonly cited proteins remaining the same over the last 10 years.
PPAR beta/delta NR1C2 LBD (aa137-441)
of Aberdeen, UK), 14 contributions are presented in sections dedicated to ligand binding and nuclear receptor
turnover, nuclear localization and DNA binding, nuclear receptor
--co- regulatory protein interactions, and pathophysiological analysis of nuclear receptor
Some results of the response for each nuclear receptor
are shown in Fig.
This protein can bind to several other nuclear receptors
to form distinct molecular complexes called heterodimers.
The LXR beta nuclear receptor
was developed jointly by Karo Bio and the US healthcare group American Home Products Corp under a collaboration agreement signed last September.
18 September 2014 - US nuclear receptor
screening specialist Indigo Biosciences said Thursday it had launched a human estrogen-related orphan receptor gamma (NR3B3; ERR?