nuclear hormone receptor

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nuclear hormone receptor

[¦nü·klē·ər ′hȯr‚mōn ri‚sep·tər]
(cell and molecular biology)
Any of a superfamily of proteins that directly regulate transcription in response to hormones and other ligands.
References in periodicals archive ?
In this report, we developed a new method for screening novel nuclear receptor agonists, and used it to identify new candidate ligands for FXR and RARs.
In addition, INDIGO Biosciences offers contract screening services for more than two dozen individual nuclear receptor reporter assays, including all nine retinoid receptors.
Our study found that Vitamin A itself is active for activating nuclear receptor TR4," said Edward Zhou, one of the investigators.
Recent evidence has shown that orphan nuclear receptors are required for many essential physiological functions in the human body, and can be used to help discover drug targets for human diseases," said Zhou.
Solvay Pharmaceuticals Conference on Nuclear Receptors as Molecular Targets for Cardiometabolic and Central Nervous System Diseases (8th: 2007: Nice, France).
The release of AurSCOPE Global Pharmacology Space (GPS), Nuclear Receptor and Protease represents an exciting milestone for Aureus Pharma.
INDIGO offers the most expansive portfolio of Nuclear Receptor tools for scientists engaged in the discovery and development of novel therapeutic agents.
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.
In less than four years, X-Ceptor has assembled a world-class scientific team of biologists, chemists and pharmacologists and developed a fully-integrated drug discovery platform for the nuclear receptor gene family.
The company's primary focus is to provide cell lines enabling rapid determination of a chemical's ability to enhance the expression of drug-metabolizing enzymes and transporters through nuclear receptor activation.
The study reveals that Sulindac shuts down cancer cell growth and initiates cell death by binding to nuclear receptor RXRa, a protein that receives a signal and carries it into the nucleus to turn genes on or off.
Topics include the development of nuclear receptor assays using AlphaScreen and LANCE technology, the preparation of cells for high-content screening, scintillation proximity assay of inositol phosphates, Aurora assays, and homogeneous multiwell assays for measuring cell viability and apoptosis.
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