nucleophile

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nucleophile

[′nü·klē·ə‚fīl]
(physical chemistry)
A species possessing one or more electron-rich sites, such as an unshared pair of electrons, the negative end of a polar bond, or pi electrons. Also known as electron donor.
References in periodicals archive ?
Thiol group of L-cysteine or GSH could act as a nucleophile to react with the alkylation agent, namely [alpha], [beta]-unsaturated ketone group in the D-ring of diterpenoids.
Vulcanized products from peroxide curable fluoroelastomers contain a much lower amount of residual double bonds and an improved resistance to nucleophiles is obtained.
Amino groups are weaker nucleophiles than thiol groups; alkaline pH values, however, can increase the reaction rate of amino groups, and under some conditions (i.
These two types of chemical species differ in their basicity, nucleophillicity, and ionization potential; as a consequence, their chemical reactivity and biotransformation may follow different pathways, resulting in several nucleophiles (62).
Recent work has centered on studying the stereoselectivity of reactions of certain [beta]-ketosulfones, in which the proximity of a sterically hindered sulfonyl group to other functional groups leads to diastereoselectivity in the reaction of nucleophiles with the carbonyl group.
All five mixed-substituent polymers were obtained by the reactions of poly(dichlorophosphazene) with the appropriate alkoxide and etheric nucleophiles.
The surface of the DNA-Bind [TM] 96-well plate (Costar) is covalently coated with a layer of reactive N-oxysuccinimide esters, which will react with nucleophiles such as primary amines.
Entitled "Oxidative Metabolism of Combretastatin A-1 Produces Quinone Intermediates with the Potential To Bind to Nucleophiles and To Enhance Oxidative Stress via Free Radicals," the article has been published ahead of print in electronic form on the website of the journal Chemical Research in Toxicology (http://pubs.
This has led us to examine latent forms of a range of N-based nucleophiles that are easily handled and can be activated by moisture and/or heat when desired.
The cleavage buffers consisted of PBS with the nucleophiles added to the indicated concentrations described under Results (0.
Thus, this study performed a detailed examination of the substitution of CI by the nucleophiles iodide ([I.