null allele

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null allele

[′nəl ə‚lēl]
(genetics)
An allele that does not produce a functional product and behaves as a recessive.
References in periodicals archive ?
The frequency of null alleles was estimated using the individual breeding model (10,000 iterations) implemented in INEst v 1.
Three loci displayed significant departure from Hardy-Weinberg equilibrium expectations, likely reflecting occurrence of null alleles.
spiniferus from 48 female individuals in which all loci also deviated from the Hardy-Weinberg equilibrium, and no loci exhibited significant evidence of null alleles.
Heterozygous null alleles in filaggrin contribute to clinical dry skin in young adults and the elderly [Letter].
Three types of errors could occur during the processes of identification and isolation using primers and amplification by PCR: null alleles (one or more alleles fail to amplify during PCR), stuttering (slight changes occur in the allele sizes during PCR) and large allele dropout (large alleles do not amplify as efficiently as small alleles) (Van Oosterhout et al.
In addition, the effects of ignoring the possible presence of null alleles on the strength of parentage evidence is also demonstrated using case work data.
We have shown that this approach enables the generation of null alleles for most human genes and can be used to pinpoint genes that are involved in phenotypes of interest.
Null alleles were also included in the overall number of alleles in a specific VNTR locus.
The PM status can be deduced with >99% certainty from the presence of 2 nonfunctional alleles, with > 20 null alleles having been identified (43).