null allele

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null allele

[′nəl ə‚lēl]
(genetics)
An allele that does not produce a functional product and behaves as a recessive.
References in periodicals archive ?
In knockout male mice, VDR null mutant were found to have gonadal insufficiency.
To substantiate that FimH was the ligand involved, several FimH plasmid constructs that have been previously described were used, including a wild type, a null mutant missing the fimH gene, a Q133K mutant, and an N46A mutant.
(a) The E3 ligase null mutant pCAF negates CIITA ubiquitination.
Moreover, mice infected with the null mutant exhibited a more organized immune response with well-formed granulomas encasing URE[DELTA] cells [81].
We demonstrated that CK1.1 was not essential for parasite survival as the null mutant parasites could survive as promastigotes and axenic amastigotes but may have a function in stationary phase.
Fgfr3 and Fgfr4 null mutant mice, on the other hand, are viable with no reproductive phenotype reported (20-22).
In contrast, the AX-dependent life span extension was not observed even in a daf-16 null mutant. Especially, the expression of genes encoding superoxide dismutases and catalases increased in two weeks after hatching, and the DAF-16 protein was translocated to the nucleus in the AX-exposed wild type.
cholerae relA null mutant cells failed to accumulate (p)ppGpp upon amino acid starvation.
Techniques to make null mutant mice include complicated steps: vector design and construction, colony selection of embryonic stem (ES) cells, production of chimera mice, confirmation of germ line transmission, and so forth.
This may be related to PKC[gamma]'s action at the [GABA.sub.A] receptor, as alcohol-enhanced inhibition of the receptor function was absent in brain tissue from the null mutant mice compared with the wild-type controls (Harris et al.
Of the two, HS1 is a myosin II null mutant that does not express conventional myosin, which is responsible for production of major mechanochemical forces (7).