Fgfr3 and Fgfr4 null mutant
mice, on the other hand, are viable with no reproductive phenotype reported (20-22).
In contrast, the AX-dependent life span extension was not observed even in a daf-16 null mutant
The resultant animal is called a null mutant
or knockout for that gene.
cholerae relA null mutant
cells failed to accumulate (p)ppGpp upon amino acid starvation.
Techniques to make null mutant
mice include complicated steps: vector design and construction, colony selection of embryonic stem (ES) cells, production of chimera mice, confirmation of germ line transmission, and so forth.
A] receptor, as alcohol-enhanced inhibition of the receptor function was absent in brain tissue from the null mutant
mice compared with the wild-type controls (Harris et al.
Of the two, HS1 is a myosin II null mutant
that does not express conventional myosin, which is responsible for production of major mechanochemical forces (7).
The propan-2-ol levels, however, were significantly higher in the null mutant
compared with Fg1 and SimM.
This was shown in particular using Galectin-1 null mutant
(gal(-1-)) mice, and confirmed by recent studies".
In contrast, a loss-of-function mutant of SCM3, fc1, and another SL synthesis null mutant
, d10, (42) exhibited not only desirable SL-related phenotypes (increased tiller number) but also unfavorable reduction in culm diameter and thickness.
lin-11 null mutant
animals display cryophilic defects that phenocopy laser ablation of the AIZ interneuron.
68) gon-1 null mutants
show a number of severe phenotypes, including sterility, but we also found that certain genes, if downregulated, suppress even such severe phenotypes (Yoshina et al.